Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

Yutaka Watanabe; Shinsuke Sofue; Shoichiro Ozaki; Masato Hirata

doi:10.1039/cc9960001815

Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

Yutaka Watanabe, Shinsuke Sofue, Shoichiro Ozaki, Masato Hirata

Oral Biological Sciences

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7 Citations (Scopus)

Abstract

Phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate), 4- and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological activity towards InsP₃ 5-phosphatase was found to be similar to or more active than that for InsP₃ while they proved to be less active in the binding assay than InsP₃.

Original language	English
Pages (from-to)	1815-1816
Number of pages	2
Journal	Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/cc9960001815
Publication status	Published - Jan 1 1996

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate), 4- and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological activity towards InsP3 5-phosphatase was found to be similar to or more active than that for InsP3 while they proved to be less active in the binding assay than InsP3.",

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AU - Watanabe, Yutaka

AU - Sofue, Shinsuke

AU - Ozaki, Shoichiro

AU - Hirata, Masato

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AB - Phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate), 4- and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological activity towards InsP3 5-phosphatase was found to be similar to or more active than that for InsP3 while they proved to be less active in the binding assay than InsP3.

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Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

Abstract

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