Synthesis of the 1β-Methylcarbapenem Key Intermediates

Yoshio Ito, Shiro Terashima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The 1β-methylcarbapenem antibiotics represented by 3, 4, and 5, have been the focus of current synthetic endeavor due to prominent antibacterial activities and broad spectra as well as enhanced chemical and metabolic stability. Progress of the syntheses of 1β-methylcarbapenem key intermediates represented by 6, are reviewed based on the synthetic methods of the characteristic 1β-methyl substituent involved in the contiguous four chiral centers of 6.

Original languageEnglish
Pages (from-to)606-618
Number of pages13
JournalJournal of Synthetic Organic Chemistry, Japan
Volume47
Issue number7
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of the 1β-Methylcarbapenem Key Intermediates'. Together they form a unique fingerprint.

  • Cite this