Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

Yosuke Taniguchi, Xiuming Cao, Shigeki Sasaki

Research output: Contribution to journalArticle

Abstract

The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this approach, it is possible to make highly-deuterated oligonucleotides for biological studies and structural analyses.

Original languageEnglish
Article number151037
JournalTetrahedron Letters
Volume60
Issue number38
DOIs
Publication statusPublished - Sep 19 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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