Synthesis, structure, DNA binding and photonuclease activity of a nickel(II) complex with a N,N′-Bis(salicylidene)-9-(3,4-diaminophenyl) acridine ligand

Mariappan Mariappan, Masahiko Suenaga, Abhik Mukhopadhyay, Bhaskar G. Maiya

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A new class of salen functionalized novel ligand N,N′- Bis(salicylidene)-9-(3,4-diaminophenyl)acridine, H 2daasal (two potential intercalators, salen and acridine, which are linked together via C-C bond) and its metal complex [Ni(daasal)] have been synthesized and characterized by X-ray diffraction, elemental analysis, UV-Vis, IR, 1H NMR, MALDI-TOF mass spectrometry and cyclic voltammetry methods. From the crystal structure, the salphen moiety is not coplanar with the acridine ring, having a dihedral angle of 68° and 76° in both H 2daasal and [Ni(daasal)], respectively. [Ni(daasal)] shows a reversible oxidation cyclic voltammetric response near 1.03 V versus SCE in CH 3CN (0.1 M TBAP) assignable to the Ni(II)/Ni(III) couple. The interaction of these compounds with calf-thymus (CT) DNA was examined using spectroscopic and viscosity measurements. These studies reveal that both compounds bind to CT DNA via an intercalative mode. Molecular-modeling studies also support an intercalative mode of binding to the model duplex d(CGCAATTGCG) 2 possibly from the major groove with a slight preference for GC rich region. Additionally, [Ni(daasal)] promotes the cleavage of plasmid pBR322 DNA upon irradiation under terminal oxidant Oxone.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalInorganica Chimica Acta
Volume390
DOIs
Publication statusPublished - Jul 15 2012

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Acridines
Nickel
Thymus
calves
DNA
deoxyribonucleic acid
Ligands
nickel
ligands
synthesis
GC Rich Sequence
Intercalating Agents
plasmids
Molecular modeling
Coordination Complexes
Viscosity measurement
Dihedral angle
Metal complexes
Oxidants
grooves

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Synthesis, structure, DNA binding and photonuclease activity of a nickel(II) complex with a N,N′-Bis(salicylidene)-9-(3,4-diaminophenyl) acridine ligand. / Mariappan, Mariappan; Suenaga, Masahiko; Mukhopadhyay, Abhik; Maiya, Bhaskar G.

In: Inorganica Chimica Acta, Vol. 390, 15.07.2012, p. 95-104.

Research output: Contribution to journalArticle

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