Synthetic Method for 2′-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction

Hiroaki Sawamoto, Yuuki Arai, Shuhei Yamakoshi, Satoshi Obika, Eiji Kawanishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A transglycosylation reaction of 2′-amino-locked nucleic acid (LNA) from thymine (T) to other nucleobases adenine (A), guanine (G), and 5-methylcytosine (mC) has been developed. This reaction proceeds in high yield and with high β-selectivity. The mild reaction conditions enable the coexistence of acid-labile protecting groups, including a 4,4′-dimethoxytrytyl (DMTr) group. 2′-Amino-LNAs bearing any nucleobase can now be easily synthesized.

Original languageEnglish
Pages (from-to)1928-1931
Number of pages4
JournalOrganic Letters
Volume20
Issue number7
DOIs
Publication statusPublished - Apr 6 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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