Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

Yasufumi Fuchi, Takashi Fukuda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A series of 9-hydroxy-1,3-diazaphenoxazine-2-one derivatives were synthesized as fluorescent receptor molecules for 8-oxo-dGTP, which attach the cyclen-zinc complex at the 3-N position as the binding site for the triphosphate and the (2-aryloxycarbonylamino)ethyl group at the 9-O position as the hydrogen bonding site for 8-oxoguanine. Among these molecules, the receptor molecule 5a-Zn constructed of the ethyl linker at 3-N and the (2-benzyloxycarbonyl amino)ethyl group at 9-O displayed the best recognition ability for 8-oxoguanosine triphosphate (8-oxo-dGTP) in aqueous media. The receptor 5a-Zn was also shown to selectively detect 8-oxo-dGTP in a cell lysate solution.

Original languageEnglish
Pages (from-to)7949-7955
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number33
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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