Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice

Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although previous studies have attempted to create "electronics-free" insulin delivery systemsusing glucose oxidase and sugar-binding lectins as a glucose-sensingmechanism, no successful clinical translation has hitherto beenmade. These protein-based materials are intolerant of long-term use and storage because of their denaturing and/or cytotoxic properties. We provide a solution by designing a protein-free and totally synthetic material-based approach. Capitalizing on the sugar-responsive properties of boronic acid, we have established a synthetic polymer gel-based insulin delivery device confined within a single catheter, which exhibits an artificial pancreas-like function in vivo. Subcutaneous implantation of the device in healthy and diabetic mice establishes a closed-loop systemcomposed of "continuous glucose sensing" and "skin layer"-regulated insulin release. As a result, glucose metabolism was controlled in response to interstitial glucose fluctuation under both insulin-deficient and insulin-resistant conditions with at least 3-week durability. Our "smart gel" technology could offer a user-friendly and remarkably economic (disposable) alternative to the current state of the art, thereby facilitating availability of effective insulin treatment not only to diabetic patients in developing countries but also to those patients who otherwise may not be strongly motivated, such as the elderly, infants, and patients in need of nursing care.

Original languageEnglish
Article numbereaaq0723
JournalScience Advances
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 2017

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Gels
Insulin
Glucose
Artificial Pancreas
Boronic Acids
Equipment and Supplies
Glucose Oxidase
Nursing Care
Lectins
Developing Countries
Polymers
Proteins
Catheters
Economics
Technology
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • General

Cite this

Matsumoto, A., Tanaka, M., Matsumoto, H., Ochi, K., Moro-Oka, Y., Kuwata, H., ... Suganami, T. (2017). Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. Science Advances, 3(11), [eaaq0723]. https://doi.org/10.1126/sciadv.aaq0723

Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. / Matsumoto, Akira; Tanaka, Miyako; Matsumoto, Hiroko; Ochi, Kozue; Moro-Oka, Yuki; Kuwata, Hirohito; Yamada, Hironori; Shirakawa, Ibuki; Miyazawa, Taiki; Ishii, Hitoshi; Kataoka, Kazunori; Ogawa, Yoshihiro; Miyahara, Yuji; Suganami, Takayoshi.

In: Science Advances, Vol. 3, No. 11, eaaq0723, 11.2017.

Research output: Contribution to journalArticle

Matsumoto, A, Tanaka, M, Matsumoto, H, Ochi, K, Moro-Oka, Y, Kuwata, H, Yamada, H, Shirakawa, I, Miyazawa, T, Ishii, H, Kataoka, K, Ogawa, Y, Miyahara, Y & Suganami, T 2017, 'Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice', Science Advances, vol. 3, no. 11, eaaq0723. https://doi.org/10.1126/sciadv.aaq0723
Matsumoto A, Tanaka M, Matsumoto H, Ochi K, Moro-Oka Y, Kuwata H et al. Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. Science Advances. 2017 Nov;3(11). eaaq0723. https://doi.org/10.1126/sciadv.aaq0723
Matsumoto, Akira ; Tanaka, Miyako ; Matsumoto, Hiroko ; Ochi, Kozue ; Moro-Oka, Yuki ; Kuwata, Hirohito ; Yamada, Hironori ; Shirakawa, Ibuki ; Miyazawa, Taiki ; Ishii, Hitoshi ; Kataoka, Kazunori ; Ogawa, Yoshihiro ; Miyahara, Yuji ; Suganami, Takayoshi. / Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. In: Science Advances. 2017 ; Vol. 3, No. 11.
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