Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.

Mariko Aso, Toshiyuki Kaneko, Morihide Nakamura, Yasuhiro Matsui, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.

Original languageEnglish
Pages (from-to)9-10
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
Publication statusPublished - Jan 1 2003

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Idoxuridine
Cytidine
Deoxyuridine
Halogens
Uridine
Lithium
Nucleosides
Salts
Sodium

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Aso, M., Kaneko, T., Nakamura, M., Matsui, Y., Koga, N., & Suemune, H. (2003). Synthetic studies and properties of N-tert-butylaminoxyl nucleosides. Nucleic acids research. Supplement (2001), (3), 9-10.

Synthetic studies and properties of N-tert-butylaminoxyl nucleosides. / Aso, Mariko; Kaneko, Toshiyuki; Nakamura, Morihide; Matsui, Yasuhiro; Koga, Noboru; Suemune, Hiroshi.

In: Nucleic acids research. Supplement (2001), No. 3, 01.01.2003, p. 9-10.

Research output: Contribution to journalArticle

Aso, M, Kaneko, T, Nakamura, M, Matsui, Y, Koga, N & Suemune, H 2003, 'Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.', Nucleic acids research. Supplement (2001), no. 3, pp. 9-10.
Aso, Mariko ; Kaneko, Toshiyuki ; Nakamura, Morihide ; Matsui, Yasuhiro ; Koga, Noboru ; Suemune, Hiroshi. / Synthetic studies and properties of N-tert-butylaminoxyl nucleosides. In: Nucleic acids research. Supplement (2001). 2003 ; No. 3. pp. 9-10.
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