Abstract
Palladium-mediated cyclization of 19 and 23 directed toward the construction of the bicyclic core (3), which would serve as a key intermediate for the total synthesis of halichlorine (1) and pinnaic acid (2), was explored and found to proceed for 19 in a highly diastereoselective manner furnishing the unnatural isomer (21), and providing a mixture of the desired product (3) and (21) for 23.
Original language | English |
---|---|
Pages (from-to) | 871-885 |
Number of pages | 15 |
Journal | Heterocycles |
Volume | 54 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1 2001 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Pharmacology
- Organic Chemistry