Synthetic studies on halichlorine and pinnaic acid: Palladium-mediated construction of the bicyclic spiro core

Wakako Yokota, Mitsuru Shindo, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Palladium-mediated cyclization of 19 and 23 directed toward the construction of the bicyclic core (3), which would serve as a key intermediate for the total synthesis of halichlorine (1) and pinnaic acid (2), was explored and found to proceed for 19 in a highly diastereoselective manner furnishing the unnatural isomer (21), and providing a mixture of the desired product (3) and (21) for 23.

Original languageEnglish
Pages (from-to)871-885
Number of pages15
JournalHeterocycles
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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