System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution

Tasha K. Altheide, Toshiyuki Hayakawa, Tarjei S. Mikkelsen, Sandra Diaz, Nissi Varki, Ajit Varki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Numerous vertebrate genes are involved in the biology of the oligosaccharide chains attached to glycoconjugates. These genes fall into diverse groups within the conventional Gene Ontology classification. However, they should be evaluated together from functional and evolutionary perspectives in a "biochemical systems" approach, considering each monosaccharide unit's biosynthesis, activation, transport, modification, transfer, recycling, degradation, and recognition. Sialic acid (Sia) residues are monosaccharides at the outer end of glycans on the cell-surface and secreted molecules of vertebrates, mediating recognition by intrinsic or extrinsic (pathogen) receptors. The availability of multiple genome sequences allows a system-wide comparison among primates and rodents of all genes directly involved in Sia biology. Taking this approach, we present further evidence for accelerated evolution in Sia-binding domains of CD33-related Sia-recognizing Ig-like lectins. Other gene classes are more conserved, including those encoding the sialyltransferases that attach Sia residues to glycans. Despite this conservation, tissue sialylation patterns are shown to differ widely among these species, presumably because of rapid evolution of sialyltransferase expression patterns. Analyses of N- and O-glycans of erythrocyte and plasma glycopeptides from these and other mammalian taxa confirmed this phenomenon. Sia modifications on these glycopeptides also appear to be undergoing rapid evolution. This rapid evolution of the sialome presumably results from the ongoing need of organisms to evade microbial pathogens that use Sia residues as receptors. The rapid evolution of Sia-binding domains of the inhibitory CD33-related Sia-recognizing Ig-like lectins is likely to be a secondary consequence, as these inhibitory receptors presumably need to keep up with recognition of the rapidly evolving "self"-sialome.

Original languageEnglish
Pages (from-to)25689-25702
Number of pages14
JournalJournal of Biological Chemistry
Volume281
Issue number35
DOIs
Publication statusPublished - Sep 1 2006

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N-Acetylneuraminic Acid
Primates
Rodentia
Genes
Sialyltransferases
Polysaccharides
Glycopeptides
Monosaccharides
Pathogens
Lectins
Vertebrates
Gene Ontology
Glycoconjugates
Biosynthesis
Recycling
Systems Analysis
Oligosaccharides
Ontology
Conservation
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents : Evidence for two modes of rapid evolution. / Altheide, Tasha K.; Hayakawa, Toshiyuki; Mikkelsen, Tarjei S.; Diaz, Sandra; Varki, Nissi; Varki, Ajit.

In: Journal of Biological Chemistry, Vol. 281, No. 35, 01.09.2006, p. 25689-25702.

Research output: Contribution to journalArticle

Altheide, Tasha K. ; Hayakawa, Toshiyuki ; Mikkelsen, Tarjei S. ; Diaz, Sandra ; Varki, Nissi ; Varki, Ajit. / System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents : Evidence for two modes of rapid evolution. In: Journal of Biological Chemistry. 2006 ; Vol. 281, No. 35. pp. 25689-25702.
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