Systemic chemotherapy of TS-1 and cisplatin for gastric signet-ring cell carcinoma presenting as cardiac tamponade

Hitoshi Kusaba, Masahiko Fujihara, Ryuichi Nagashima, Yoshikazu Kaji, Eishi Baba, Shuji Nakano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 59-year-old man complaining of dyspnea, anterior chest oppression, and hypotension was diagnosed to have cardiac tamponade due to massive pericardial effusion. A cytological analysis of the pericardial effusion disclosed adenocarcinoma. An endoscopic study revealed gastric cancer in the lesser curvature wall of the middle body of the stomach, and signet-ring cell carcinoma was confirmed histologically. The gastric cancer was complicated by malignant pericardial effusion, and metastasis to the mediastinal lymph nodes. The patient was treated with pericardiocentesis followed by systemic chemotherapy consisting of TS-1 and cisplatin (CDDP). After 5 months, pericardial effusion disappeared and the primary gastric tumor decreased in size. Our experience suggests that the systemic chemotherapy of TS-1 and CDDP may be effective for controlling advanced gastric signet-cell carcinoma accompanied by malignant pericardial effusion.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalMedical Oncology
Volume25
Issue number2
DOIs
Publication statusPublished - Jun 1 2008

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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