TY - JOUR
T1 - Systemic effects of orally administered p, p′-DDE on immature male Wistar rats during pubertal period
AU - Makita, Yuji
AU - Matsuura, Toshiaki
AU - Ogata, Rika
AU - Romero, Yesid
AU - Omura, Minoru
AU - Tanaka, Akiyo
AU - Hirata, Miyuki
AU - Inoue, Naohide
PY - 2003/7
Y1 - 2003/7
N2 - Systemic effects of p, p′-DDE (1, 1-dichloro-2, 2 bis (p-chlorophenyl) ethylene; DDE) on immature male rats were investigated in pubertal Wistar rats after oral administration of DDE. Special rat chow containing 125 ppm DDE (approximately 10 mg/kg DDE) had been administered daily for 42 d since 6 wk of age and its effects had been observed until 12 wk of age. The administration of DDE did not produce any overt signs of toxicity. Neither physical development nor sexual maturation was affected, and serum biochemistry was not impaired at the dose used in this experiment. Moreover, the male reproductive organs and epididymal sperm count were not affected by the administration of DDE during the pubertal period. Our results showed that even immature male rats were resistant to DDE exposure at the daily dose of ca. 10 mg/kg, but metabolic and immunological changes still remained uncertain. Further investigation should be conducted to reveal all the effects of DDE on immature male rats.
AB - Systemic effects of p, p′-DDE (1, 1-dichloro-2, 2 bis (p-chlorophenyl) ethylene; DDE) on immature male rats were investigated in pubertal Wistar rats after oral administration of DDE. Special rat chow containing 125 ppm DDE (approximately 10 mg/kg DDE) had been administered daily for 42 d since 6 wk of age and its effects had been observed until 12 wk of age. The administration of DDE did not produce any overt signs of toxicity. Neither physical development nor sexual maturation was affected, and serum biochemistry was not impaired at the dose used in this experiment. Moreover, the male reproductive organs and epididymal sperm count were not affected by the administration of DDE during the pubertal period. Our results showed that even immature male rats were resistant to DDE exposure at the daily dose of ca. 10 mg/kg, but metabolic and immunological changes still remained uncertain. Further investigation should be conducted to reveal all the effects of DDE on immature male rats.
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U2 - 10.1539/joh.45.223
DO - 10.1539/joh.45.223
M3 - Article
C2 - 14646280
AN - SCOPUS:0042973756
VL - 45
SP - 223
EP - 227
JO - Journal of Occupational Health
JF - Journal of Occupational Health
SN - 1341-9145
IS - 4
ER -
