Abstract
T cells play a central role in the immunopathogenesis of AIH. Until recently CD4+ T cells were thought to be critical for disease development, increasing evidence has shown that CD8+ T and γδ T cells also play a significant role. The predisposition of certain HLA genotypes to AIH as well as the clonal expansion of a limited number of T cell receptors suggests that the presentation of a self-antigen or a molecular mimic may be responsible for the initiation of the immune response. Given the association of AIH with viral hepatitis, it is thought that the loss of tolerance begins with an infection of hepatocytes and subsequent cytolysis by CD8+ T cells. The presentation of self-antigens or molecular mimics leads to activation and clonal expansion of T cells; this process may be increased by impaired regulatory T cells and a defect in apoptosis. Ultimately T cells initiate B cell production of autoantibodies, proinflammatory cytokines and finally hepatocyte cytotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 315-321 |
| Number of pages | 7 |
| Journal | Autoimmunity Reviews |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jun 1 2005 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
Cite this
T cell immunity in autoimmune hepatitis. / Ichiki, Yasunori; Aoki, Christopher A.; Bowlus, Christopher L.; Shimoda, Shinji; Ishibashi, Hiromi; Gershwin, M. Eric.
In: Autoimmunity Reviews, Vol. 4, No. 5, 01.06.2005, p. 315-321.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - T cell immunity in autoimmune hepatitis
AU - Ichiki, Yasunori
AU - Aoki, Christopher A.
AU - Bowlus, Christopher L.
AU - Shimoda, Shinji
AU - Ishibashi, Hiromi
AU - Gershwin, M. Eric
PY - 2005/6/1
Y1 - 2005/6/1
N2 - T cells play a central role in the immunopathogenesis of AIH. Until recently CD4+ T cells were thought to be critical for disease development, increasing evidence has shown that CD8+ T and γδ T cells also play a significant role. The predisposition of certain HLA genotypes to AIH as well as the clonal expansion of a limited number of T cell receptors suggests that the presentation of a self-antigen or a molecular mimic may be responsible for the initiation of the immune response. Given the association of AIH with viral hepatitis, it is thought that the loss of tolerance begins with an infection of hepatocytes and subsequent cytolysis by CD8+ T cells. The presentation of self-antigens or molecular mimics leads to activation and clonal expansion of T cells; this process may be increased by impaired regulatory T cells and a defect in apoptosis. Ultimately T cells initiate B cell production of autoantibodies, proinflammatory cytokines and finally hepatocyte cytotoxicity.
AB - T cells play a central role in the immunopathogenesis of AIH. Until recently CD4+ T cells were thought to be critical for disease development, increasing evidence has shown that CD8+ T and γδ T cells also play a significant role. The predisposition of certain HLA genotypes to AIH as well as the clonal expansion of a limited number of T cell receptors suggests that the presentation of a self-antigen or a molecular mimic may be responsible for the initiation of the immune response. Given the association of AIH with viral hepatitis, it is thought that the loss of tolerance begins with an infection of hepatocytes and subsequent cytolysis by CD8+ T cells. The presentation of self-antigens or molecular mimics leads to activation and clonal expansion of T cells; this process may be increased by impaired regulatory T cells and a defect in apoptosis. Ultimately T cells initiate B cell production of autoantibodies, proinflammatory cytokines and finally hepatocyte cytotoxicity.
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UR - http://www.scopus.com/inward/citedby.url?scp=21244475056&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2005.01.005
DO - 10.1016/j.autrev.2005.01.005
M3 - Review article
C2 - 15990080
AN - SCOPUS:21244475056
VL - 4
SP - 315
EP - 321
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 5
ER -