T-cell lymphoproliferative disorder involving the central nervous system in two cases

Satoshi Inoha, Takanori Inamura, Shouichi Ohga, Toshiro Hara, Masashi Fukui

Research output: Contribution to journalArticle

Abstract

Lymphoproliferative disorder (LPD) sometimes occurs in immunosuppressive patients. B-cell proliferation is predominantly seen in patients with LPD and T-cell proliferation is rare. We here report two patients with T-cell LPD involving the central nervous system (CNS). A 7-year-old boy developed increased intracranial pressure and computed tomography showed a ring- enhanced mass lesion in the right frontal lobe. A 10-year-old boy developed gait disturbance and magnetic resonance imaging showed a non-enhanced lesion in the left parietal lobe. Radiological findings could not differentiate CNS- LPD from other intracranial diseases. Only histologic examination could diagnose LPD in both cases, and Epstein-Barr virus associated RNA was found in the infiltrated T-cell of the latter case. Although chemotherapy with antitumor agents was effective for remission of LPD in both cases, both patients died 3 years after their operations. As CNS-LPD shows rapid progression and frequently results in fatality, this disease requires immediate histologic diagnosis followed by extensive chemotherapy.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalNeurological Surgery
Volume28
Issue number5
Publication statusPublished - May 1 2000

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Lymphoproliferative Disorders
Central Nervous System
T-Lymphocytes
Central Nervous System Diseases
Cell Proliferation
Drug Therapy
Parietal Lobe
Intracranial Pressure
Frontal Lobe
Immunosuppressive Agents
Human Herpesvirus 4
Gait
Antineoplastic Agents
B-Lymphocytes
Tomography
Magnetic Resonance Imaging
RNA

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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T-cell lymphoproliferative disorder involving the central nervous system in two cases. / Inoha, Satoshi; Inamura, Takanori; Ohga, Shouichi; Hara, Toshiro; Fukui, Masashi.

In: Neurological Surgery, Vol. 28, No. 5, 01.05.2000, p. 435-439.

Research output: Contribution to journalArticle

Inoha, S, Inamura, T, Ohga, S, Hara, T & Fukui, M 2000, 'T-cell lymphoproliferative disorder involving the central nervous system in two cases', Neurological Surgery, vol. 28, no. 5, pp. 435-439.
Inoha, Satoshi ; Inamura, Takanori ; Ohga, Shouichi ; Hara, Toshiro ; Fukui, Masashi. / T-cell lymphoproliferative disorder involving the central nervous system in two cases. In: Neurological Surgery. 2000 ; Vol. 28, No. 5. pp. 435-439.
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