T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody

Tomomi Yonekawa, Takuya Matsushita, Motozumi Minohara, Noriko Isobe, Katsuhisa Masaki, Satoshi Yoshimura, Yasuharu Nishimura, Jun-Ichi Kira

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We previously reported the establishment of major myelin protein-derived T cell lines from 11 patients with multiple sclerosis. In the present study, we determined anti-aquaporin-4 (AQP4) antibody status in these patients and classified them into five patients with anti-AQP4 antibody who met the criteria for neuromyelitis optica (NMO) or NMO spectrum disorders, and six patients without anti-AQP4 antibody who fulfilled the revised McDonald criteria for multiple sclerosis. T cell lines reactive to myelin oligodendrocyte glycoprotein, proteolipid protein and myelin basic protein were detected in 5/5, 3/5 and 3/5 of the anti-AQP4 antibody-positive patients, respectively, and in 5/6, 4/6 and 4/6 of the anti-AQP4 antibody-negative ones, respectively. T cell lines from most of these patients showed inter- or intra-molecular epitope spreading, irrespective of anti-AQP4 antibody status. These findings suggest that T cells are stimulated in vivo against major myelin proteins in anti-AQP4 antibody-positive patients with NMO/NMO spectrum disorders.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalNeurology Asia
Volume16
Issue number2
Publication statusPublished - Jun 1 2011

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Aquaporin 4
Neuromyelitis Optica
Myelin Proteins
T-Lymphocytes
Peptides
Antibodies
Cell Line
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
Proteolipids
Myelin Basic Protein
Epitopes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

T cell reactivities to myelin protein-derived peptides in neuromyelitis optica patients with anti-aquaporin-4 antibody. / Yonekawa, Tomomi; Matsushita, Takuya; Minohara, Motozumi; Isobe, Noriko; Masaki, Katsuhisa; Yoshimura, Satoshi; Nishimura, Yasuharu; Kira, Jun-Ichi.

In: Neurology Asia, Vol. 16, No. 2, 01.06.2011, p. 139-142.

Research output: Contribution to journalArticle

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