t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization

Hidekazu Nishizawa, Masaya Baba, Mitsuko Furuya, Ikuma Kato, Ryoma Kurahashi, Yumi Honda, Yoshiki Mikami, Yoji Nagashima, Masatoshi Eto, Tomomi Kamba

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Definitive diagnosis of translocation renal cell carcinoma is challenging. We herein experienced a case of translocation(6;11) renal cell carcinoma, successfully diagnosed by using fluorescence in situ hybridization. Case presentation: During the follow-up of a 21-year-old man with Crohn's disease, computed tomography revealed a 40-mm mass in the right kidney. Since imaging could not exclude malignancy, needle biopsy was performed. The histological diagnosis from the biopsy specimen was renal cell carcinoma, but histological typing had not been done adequately. A laparoscopic partial nephrectomy was then performed. Transcription factor EB immunoreactivity was positive, transcription factor EB rearrangement was shown by break apart and fusion fluorescence in situ hybridization. As a result, a definitive diagnosis of t(6; 11) renal cell carcinoma was made. There has been no recurrence for 5 years. Conclusion: Transcription factor EB immunohistochemistry and fluorescence in situ hybridization are useful diagnostic tools for renal tumors of young generation.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalIJU Case Reports
Volume4
Issue number6
DOIs
Publication statusPublished - Nov 2021

All Science Journal Classification (ASJC) codes

  • Urology

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