Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Daiki Funamoto, Daisuke Asai, Chan Woo Kim, Yuta Nakamura, Eun Kyung Lee, Takanobu Nobori, Takuro Niidome, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

Original languageEnglish
Pages (from-to)474-476
Number of pages3
JournalChemistry Letters
Volume44
Issue number4
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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