Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Daiki Funamoto; Daisuke Asai; Chan Woo Kim; Yuta Nakamura; Eun Kyung Lee; Takanobu Nobori; Takuro Niidome; Takeshi Mori; Yoshiki Katayama

doi:10.1246/cl.141121

Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Daiki Funamoto, Daisuke Asai, Chan Woo Kim, Yuta Nakamura, Eun Kyung Lee, Takanobu Nobori, Takuro Niidome, Takeshi Mori, Yoshiki Katayama

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Abstract

We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

Original language	English
Pages (from-to)	474-476
Number of pages	3
Journal	Chemistry Letters
Volume	44
Issue number	4
DOIs	https://doi.org/10.1246/cl.141121
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.141121

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abstract = "We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.",

author = "Daiki Funamoto and Daisuke Asai and Kim, {Chan Woo} and Yuta Nakamura and Lee, {Eun Kyung} and Takanobu Nobori and Takuro Niidome and Takeshi Mori and Yoshiki Katayama",

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journal = "Chemistry Letters",

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T1 - Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

AU - Funamoto, Daiki

AU - Asai, Daisuke

AU - Kim, Chan Woo

AU - Nakamura, Yuta

AU - Lee, Eun Kyung

AU - Nobori, Takanobu

AU - Niidome, Takuro

AU - Mori, Takeshi

AU - Katayama, Yoshiki

PY - 2015

Y1 - 2015

N2 - We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

AB - We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

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U2 - 10.1246/cl.141121

DO - 10.1246/cl.141121

M3 - Article

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SP - 474

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JO - Chemistry Letters

JF - Chemistry Letters

IS - 4

ER -

Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Abstract

All Science Journal Classification (ASJC) codes

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