Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting e{open} germline transcription induced by STAT6 activation

Yoon Hee Kim, Miki Yoshimoto, Kazuko Nakayama, Sousuke Tanino, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Interleukin (IL)-4 is a critical stimulator that induces e{open} germline transcripts (e{open}GT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced e{open}GT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4Rα, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced e{open}GT expression and the IL-4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalFEBS Open Bio
Volume3
DOIs
Publication statusPublished - Jul 1 2013

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Tannins
Transcription
Interleukin-4
Immunoglobulin E
Chemical activation
Antigens
Interleukins
Ovalbumin
Genetic Recombination
pentagalloylglucose
Switches

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting e{open} germline transcription induced by STAT6 activation. / Kim, Yoon Hee; Yoshimoto, Miki; Nakayama, Kazuko; Tanino, Sousuke; Fujimura, Yoshinori; Yamada, Koji; Tachibana, Hirofumi.

In: FEBS Open Bio, Vol. 3, 01.07.2013, p. 341-345.

Research output: Contribution to journalArticle

Kim, Yoon Hee ; Yoshimoto, Miki ; Nakayama, Kazuko ; Tanino, Sousuke ; Fujimura, Yoshinori ; Yamada, Koji ; Tachibana, Hirofumi. / Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting e{open} germline transcription induced by STAT6 activation. In: FEBS Open Bio. 2013 ; Vol. 3. pp. 341-345.
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AU - Yamada, Koji

AU - Tachibana, Hirofumi

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