Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation

Yoon Hee Kim, Miki Yoshimoto, Kazuko Nakayama, Sousuke Tanino, Yoshinori Fujimura, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Interleukin (IL)-4 is a critical stimulator that induces e{open} germline transcripts (e{open}GT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced e{open}GT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4Rα, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced e{open}GT expression and the IL-4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalFEBS Open Bio
Volume3
DOIs
Publication statusPublished - Jul 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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