Target-Based Drug Repositioning Using Large-Scale Chemical-Protein Interactome Data

Ryusuke Sawada, Hiroaki Iwata, Sayaka Mizutani, Yoshihiro Yamanishi

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    Drug repositioning, or the identification of new indications for known drugs, is a useful strategy for drug discovery. In this study, we developed novel computational methods to predict potential drug targets and new drug indications for systematic drug repositioning using large-scale chemical-protein interactome data. We explored the target space of drugs (including primary targets and off-targets) based on chemical structure similarity and phenotypic effect similarity by making optimal use of millions of compound-protein interactions. On the basis of the target profiles of drugs, we constructed statistical models to predict new drug indications for a wide range of diseases with various molecular features. The proposed method outperformed previous methods in terms of interpretability, applicability, and accuracy. Finally, we conducted a comprehensive prediction of the drug-target-disease association network for 8270 drugs and 1401 diseases and showed biologically meaningful examples of newly predicted drug targets and drug indications. The predictive model is useful to understand the mechanisms of the predicted drug indications.

    Original languageEnglish
    Pages (from-to)2717-2730
    Number of pages14
    JournalJournal of Chemical Information and Modeling
    Volume55
    Issue number12
    DOIs
    Publication statusPublished - Dec 28 2015

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Chemical Engineering(all)
    • Computer Science Applications
    • Library and Information Sciences

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