Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension

Takeo Fujino, Atsushi Yao, Masaru Hatano, Toshiro Inaba, Hironori Muraoka, Shun Minatsuki, Teruhiko Imamura, Hisataka Maki, Koichiro Kinugawa, Minoru Ono, Ryozo Nagai, Issei Komuro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Therapeutic strategies for pulmonary arterial hypertension (PAH) associated with atrial septal defect (ASD) remain a matter of debate. Methods and Results: We identifed 5 outpatients who had been diagnosed with ASD-PAH and undergone ASD closure in combination with targeted therapy with certifed PAH drugs. We assessed changes in hemodynamic parameters and exercise capacity. The combination of ASD closure and targeted therapy signifcantly increased systemic blood fow (Qs) from the baseline (from 3.3 ± 0.6 L/minute to 4.2 , 1.0 L/minute, P < 0.05) with a significant improvement in the World Health Organization Functional Class (WHO-FC; from 2.8 ± 0.4 to 1.6 ± 0.5, P < 0.05). The hemodynamic data before and after ASD closure without targeted therapy showed further elevation of pulmonary vascular resistance shortly after ASD closure (678 dynes/cm5 to 926 dynes/cm5) in 1 case, as well as after a long time since ASD closure (491.0 ± 53.7 dynes/cm5 to 1045.0 ± 217.8 dynes/cm5) in 2 cases. This worsening was reversed after the targeted therapy, accompanied by an increase in Qs and an improvement in WHO-FC in all cases. Conclusions: Targeted therapy should be added to ASD closure in adult patients with ASD-PAH.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalInternational heart journal
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Atrial Heart Septal Defects
Pulmonary Hypertension
Therapeutics
Hemodynamics
Vascular Resistance
Outpatients
Exercise

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension. / Fujino, Takeo; Yao, Atsushi; Hatano, Masaru; Inaba, Toshiro; Muraoka, Hironori; Minatsuki, Shun; Imamura, Teruhiko; Maki, Hisataka; Kinugawa, Koichiro; Ono, Minoru; Nagai, Ryozo; Komuro, Issei.

In: International heart journal, Vol. 56, No. 1, 01.01.2015, p. 86-93.

Research output: Contribution to journalArticle

Fujino, T, Yao, A, Hatano, M, Inaba, T, Muraoka, H, Minatsuki, S, Imamura, T, Maki, H, Kinugawa, K, Ono, M, Nagai, R & Komuro, I 2015, 'Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension', International heart journal, vol. 56, no. 1, pp. 86-93. https://doi.org/10.1536/ihj.14-183
Fujino, Takeo ; Yao, Atsushi ; Hatano, Masaru ; Inaba, Toshiro ; Muraoka, Hironori ; Minatsuki, Shun ; Imamura, Teruhiko ; Maki, Hisataka ; Kinugawa, Koichiro ; Ono, Minoru ; Nagai, Ryozo ; Komuro, Issei. / Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension. In: International heart journal. 2015 ; Vol. 56, No. 1. pp. 86-93.
@article{0e645fb75d4a4ab9b60e342d41681661,
title = "Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension",
abstract = "Background: Therapeutic strategies for pulmonary arterial hypertension (PAH) associated with atrial septal defect (ASD) remain a matter of debate. Methods and Results: We identifed 5 outpatients who had been diagnosed with ASD-PAH and undergone ASD closure in combination with targeted therapy with certifed PAH drugs. We assessed changes in hemodynamic parameters and exercise capacity. The combination of ASD closure and targeted therapy signifcantly increased systemic blood fow (Qs) from the baseline (from 3.3 ± 0.6 L/minute to 4.2 , 1.0 L/minute, P < 0.05) with a significant improvement in the World Health Organization Functional Class (WHO-FC; from 2.8 ± 0.4 to 1.6 ± 0.5, P < 0.05). The hemodynamic data before and after ASD closure without targeted therapy showed further elevation of pulmonary vascular resistance shortly after ASD closure (678 dynes/cm5 to 926 dynes/cm5) in 1 case, as well as after a long time since ASD closure (491.0 ± 53.7 dynes/cm5 to 1045.0 ± 217.8 dynes/cm5) in 2 cases. This worsening was reversed after the targeted therapy, accompanied by an increase in Qs and an improvement in WHO-FC in all cases. Conclusions: Targeted therapy should be added to ASD closure in adult patients with ASD-PAH.",
author = "Takeo Fujino and Atsushi Yao and Masaru Hatano and Toshiro Inaba and Hironori Muraoka and Shun Minatsuki and Teruhiko Imamura and Hisataka Maki and Koichiro Kinugawa and Minoru Ono and Ryozo Nagai and Issei Komuro",
year = "2015",
month = "1",
day = "1",
doi = "10.1536/ihj.14-183",
language = "English",
volume = "56",
pages = "86--93",
journal = "International Heart Journal",
issn = "1349-2365",
publisher = "International Heart Journal Association",
number = "1",

}

TY - JOUR

T1 - Targeted therapy is required for management of pulmonary arterial hypertension after defect closure in adult patients with atrial septal defect and associated pulmonary arterial hypertension

AU - Fujino, Takeo

AU - Yao, Atsushi

AU - Hatano, Masaru

AU - Inaba, Toshiro

AU - Muraoka, Hironori

AU - Minatsuki, Shun

AU - Imamura, Teruhiko

AU - Maki, Hisataka

AU - Kinugawa, Koichiro

AU - Ono, Minoru

AU - Nagai, Ryozo

AU - Komuro, Issei

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Therapeutic strategies for pulmonary arterial hypertension (PAH) associated with atrial septal defect (ASD) remain a matter of debate. Methods and Results: We identifed 5 outpatients who had been diagnosed with ASD-PAH and undergone ASD closure in combination with targeted therapy with certifed PAH drugs. We assessed changes in hemodynamic parameters and exercise capacity. The combination of ASD closure and targeted therapy signifcantly increased systemic blood fow (Qs) from the baseline (from 3.3 ± 0.6 L/minute to 4.2 , 1.0 L/minute, P < 0.05) with a significant improvement in the World Health Organization Functional Class (WHO-FC; from 2.8 ± 0.4 to 1.6 ± 0.5, P < 0.05). The hemodynamic data before and after ASD closure without targeted therapy showed further elevation of pulmonary vascular resistance shortly after ASD closure (678 dynes/cm5 to 926 dynes/cm5) in 1 case, as well as after a long time since ASD closure (491.0 ± 53.7 dynes/cm5 to 1045.0 ± 217.8 dynes/cm5) in 2 cases. This worsening was reversed after the targeted therapy, accompanied by an increase in Qs and an improvement in WHO-FC in all cases. Conclusions: Targeted therapy should be added to ASD closure in adult patients with ASD-PAH.

AB - Background: Therapeutic strategies for pulmonary arterial hypertension (PAH) associated with atrial septal defect (ASD) remain a matter of debate. Methods and Results: We identifed 5 outpatients who had been diagnosed with ASD-PAH and undergone ASD closure in combination with targeted therapy with certifed PAH drugs. We assessed changes in hemodynamic parameters and exercise capacity. The combination of ASD closure and targeted therapy signifcantly increased systemic blood fow (Qs) from the baseline (from 3.3 ± 0.6 L/minute to 4.2 , 1.0 L/minute, P < 0.05) with a significant improvement in the World Health Organization Functional Class (WHO-FC; from 2.8 ± 0.4 to 1.6 ± 0.5, P < 0.05). The hemodynamic data before and after ASD closure without targeted therapy showed further elevation of pulmonary vascular resistance shortly after ASD closure (678 dynes/cm5 to 926 dynes/cm5) in 1 case, as well as after a long time since ASD closure (491.0 ± 53.7 dynes/cm5 to 1045.0 ± 217.8 dynes/cm5) in 2 cases. This worsening was reversed after the targeted therapy, accompanied by an increase in Qs and an improvement in WHO-FC in all cases. Conclusions: Targeted therapy should be added to ASD closure in adult patients with ASD-PAH.

UR - http://www.scopus.com/inward/record.url?scp=84921842228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921842228&partnerID=8YFLogxK

U2 - 10.1536/ihj.14-183

DO - 10.1536/ihj.14-183

M3 - Article

C2 - 25742945

AN - SCOPUS:84921842228

VL - 56

SP - 86

EP - 93

JO - International Heart Journal

JF - International Heart Journal

SN - 1349-2365

IS - 1

ER -