Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells

Mamiko Ise, Hirohiko Ise, Yuji Shiba, Satoshi Kobayashi, Mitsuaki Goto, Masafumi Takahashi, Toshihiro Akaike, Uichi Ikeda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The targeted delivery of anti-inflammatory agents has great therapeutic potential for treating restenosis following percutaneous coronary intervention. To develop a drug delivery system targeted to injured blood vessels, we examined whether N-acetylglucosamine (GlcNAc)-bearing polymer-coated liposomes (GlcNAc-Ls) are specifically taken up by vascular smooth muscle cells (VSMCs). Flow cytometric analysis revealed that GlcNAc-Ls were taken up by VSMCs in vitro. Furthermore, GlcNAc-Ls were intravenously administered to mice that had undergone wire-mediated vascular injury. GlcNAc-Ls markedly accumulated at the intramural site of the injured vessel walls but not at the contralateral (uninjured) vessel walls. These results demonstrated that GlcNAc-Ls can be specifically taken up by VSMCs both in vitro and in vivo. We propose a novel strategy of using GlcNAc-Ls that has potential for application in drug delivery targeted to injured blood vessels.

Original languageEnglish
Pages (from-to)301-309
Number of pages9
JournalJournal of Artificial Organs
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 1 2011

Fingerprint

Bearings (structural)
Acetylglucosamine
Liposomes
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Polymers
Cells
Blood vessels
Blood Vessels
Vascular System Injuries
Percutaneous Coronary Intervention
Drug Delivery Systems
Anti-Inflammatory Agents
Wire

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

Cite this

Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells. / Ise, Mamiko; Ise, Hirohiko; Shiba, Yuji; Kobayashi, Satoshi; Goto, Mitsuaki; Takahashi, Masafumi; Akaike, Toshihiro; Ikeda, Uichi.

In: Journal of Artificial Organs, Vol. 14, No. 4, 01.12.2011, p. 301-309.

Research output: Contribution to journalArticle

Ise, M, Ise, H, Shiba, Y, Kobayashi, S, Goto, M, Takahashi, M, Akaike, T & Ikeda, U 2011, 'Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells', Journal of Artificial Organs, vol. 14, no. 4, pp. 301-309. https://doi.org/10.1007/s10047-011-0595-3
Ise, Mamiko ; Ise, Hirohiko ; Shiba, Yuji ; Kobayashi, Satoshi ; Goto, Mitsuaki ; Takahashi, Masafumi ; Akaike, Toshihiro ; Ikeda, Uichi. / Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells. In: Journal of Artificial Organs. 2011 ; Vol. 14, No. 4. pp. 301-309.
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