Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells

Mamiko Ise, Hirohiko Ise, Yuji Shiba, Satoshi Kobayashi, Mitsuaki Goto, Masafumi Takahashi, Toshihiro Akaike, Uichi Ikeda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The targeted delivery of anti-inflammatory agents has great therapeutic potential for treating restenosis following percutaneous coronary intervention. To develop a drug delivery system targeted to injured blood vessels, we examined whether N-acetylglucosamine (GlcNAc)-bearing polymer-coated liposomes (GlcNAc-Ls) are specifically taken up by vascular smooth muscle cells (VSMCs). Flow cytometric analysis revealed that GlcNAc-Ls were taken up by VSMCs in vitro. Furthermore, GlcNAc-Ls were intravenously administered to mice that had undergone wire-mediated vascular injury. GlcNAc-Ls markedly accumulated at the intramural site of the injured vessel walls but not at the contralateral (uninjured) vessel walls. These results demonstrated that GlcNAc-Ls can be specifically taken up by VSMCs both in vitro and in vivo. We propose a novel strategy of using GlcNAc-Ls that has potential for application in drug delivery targeted to injured blood vessels.

Original languageEnglish
Pages (from-to)301-309
Number of pages9
JournalJournal of Artificial Organs
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

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