Targeting the Wnt/β-catenin signaling pathway in human cancers

Hisayuki Yao, Eishi Ashihara, Taira Maekawa

Research output: Contribution to journalReview article

108 Citations (Scopus)

Abstract

Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed. Areas covered: This review discusses the potential of inhibiting the Wnt/β-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/β-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/β-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/β-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

Original languageEnglish
Pages (from-to)873-887
Number of pages15
JournalExpert Opinion on Therapeutic Targets
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 1 2011
Externally publishedYes

Fingerprint

Catenins
Wnt Signaling Pathway
Stem cells
Neoplasms
Neoplastic Stem Cells
Screening
Expert Testimony
Cell growth
Biomarkers
Growth and Development
Cell Differentiation
Stem Cells
Chemical activation
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Targeting the Wnt/β-catenin signaling pathway in human cancers. / Yao, Hisayuki; Ashihara, Eishi; Maekawa, Taira.

In: Expert Opinion on Therapeutic Targets, Vol. 15, No. 7, 01.07.2011, p. 873-887.

Research output: Contribution to journalReview article

Yao, Hisayuki ; Ashihara, Eishi ; Maekawa, Taira. / Targeting the Wnt/β-catenin signaling pathway in human cancers. In: Expert Opinion on Therapeutic Targets. 2011 ; Vol. 15, No. 7. pp. 873-887.
@article{837a9687f4484582847a515db7c14f05,
title = "Targeting the Wnt/β-catenin signaling pathway in human cancers",
abstract = "Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed. Areas covered: This review discusses the potential of inhibiting the Wnt/β-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/β-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/β-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/β-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.",
author = "Hisayuki Yao and Eishi Ashihara and Taira Maekawa",
year = "2011",
month = "7",
day = "1",
doi = "10.1517/14728222.2011.577418",
language = "English",
volume = "15",
pages = "873--887",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "7",

}

TY - JOUR

T1 - Targeting the Wnt/β-catenin signaling pathway in human cancers

AU - Yao, Hisayuki

AU - Ashihara, Eishi

AU - Maekawa, Taira

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed. Areas covered: This review discusses the potential of inhibiting the Wnt/β-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/β-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/β-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/β-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

AB - Introduction: The Wnt/β-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed. Areas covered: This review discusses the potential of inhibiting the Wnt/β-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/β-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/β-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/β-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

UR - http://www.scopus.com/inward/record.url?scp=79958280454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958280454&partnerID=8YFLogxK

U2 - 10.1517/14728222.2011.577418

DO - 10.1517/14728222.2011.577418

M3 - Review article

C2 - 21486121

AN - SCOPUS:79958280454

VL - 15

SP - 873

EP - 887

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 7

ER -