Taste preference for fatty acids is mediated by GPR40 and GPR120

Cristina Cartoni, Keiko Yasumatsu, Tadahiro Ohkuri, Noriatsu Shigemura, Ryusuke Yoshida, Nicolas Godinot, Johannes Le Coutre, Yuzo Ninomiya, Sami Damak

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

The oral perception of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fatty acids. The two G-protein coupled receptors GPR40 (Ffar1) and GPR120 are activated by medium and long chain fatty acids. Here we show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses to several fatty acids. These results show that GPR40 and GPR120 mediate the taste of fatty acids.

Original languageEnglish
Pages (from-to)8376-8382
Number of pages7
JournalJournal of Neuroscience
Volume30
Issue number25
DOIs
Publication statusPublished - Jun 23 2010

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Fatty Acids
Taste Buds
Smell
Linoleic Acid
Oleic Acid
G-Protein-Coupled Receptors
Knockout Mice
Fats

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Cartoni, C., Yasumatsu, K., Ohkuri, T., Shigemura, N., Yoshida, R., Godinot, N., ... Damak, S. (2010). Taste preference for fatty acids is mediated by GPR40 and GPR120. Journal of Neuroscience, 30(25), 8376-8382. https://doi.org/10.1523/JNEUROSCI.0496-10.2010

Taste preference for fatty acids is mediated by GPR40 and GPR120. / Cartoni, Cristina; Yasumatsu, Keiko; Ohkuri, Tadahiro; Shigemura, Noriatsu; Yoshida, Ryusuke; Godinot, Nicolas; Le Coutre, Johannes; Ninomiya, Yuzo; Damak, Sami.

In: Journal of Neuroscience, Vol. 30, No. 25, 23.06.2010, p. 8376-8382.

Research output: Contribution to journalArticle

Cartoni, C, Yasumatsu, K, Ohkuri, T, Shigemura, N, Yoshida, R, Godinot, N, Le Coutre, J, Ninomiya, Y & Damak, S 2010, 'Taste preference for fatty acids is mediated by GPR40 and GPR120', Journal of Neuroscience, vol. 30, no. 25, pp. 8376-8382. https://doi.org/10.1523/JNEUROSCI.0496-10.2010
Cartoni, Cristina ; Yasumatsu, Keiko ; Ohkuri, Tadahiro ; Shigemura, Noriatsu ; Yoshida, Ryusuke ; Godinot, Nicolas ; Le Coutre, Johannes ; Ninomiya, Yuzo ; Damak, Sami. / Taste preference for fatty acids is mediated by GPR40 and GPR120. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 25. pp. 8376-8382.
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