TCR-independent activation of extrathymically developed, self antigen- specific T cells by IL-2/IL-15

Hisakata Yamada, Takahiko Nakamura, Goro Matsuzaki, Yukihide Iwamoto, Kikuo Nomoto

Research output: Contribution to journalArticle

Abstract

Naive intrathymically developed T cells, which express foreign Ag- specific TCR, do not express IL-2R. After antigenic stimulation, they express high affinity IL-2R, which enables IL-2 to be used as an autocrine growth factor. On the contrary, extrathymically developed T cells, which express self Ag-specific TCR but are unresponsive to antigenic stimulation, spontaneously express low affinity IL-2R. In this study, we compared the responses of these two subsets of T cells to IL-2R stimulation and examined the influences of TCR-mediated signaling on the responses. IL-2 or IL-15 augmented the proliferative response of Ag-stimulated, intrathymically developed T cells. On the other hand, extrathymically developed T cells proliferated in response to IL-2 or IL-15, independently of Ag stimulation. Furthermore, both IL-2 and IL-15 induced IFN-γ production of these T cells, which is strikingly augmented by the presence of IL-12. These results revealed functional differences between intrathymically developed, foreign Ag-specific T cells and extrathymically developed, self Ag-specific T cells. The latter can be activated by some inflammatory cytokines, in an Ag- independent manner, similar to NK cells.

Original languageEnglish
Pages (from-to)1746-1752
Number of pages7
JournalJournal of Immunology
Volume164
Issue number4
DOIs
Publication statusPublished - Feb 15 2000

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Interleukin-15
Autoantigens
Interleukin-2
T-Lymphocytes
T-Lymphocyte Subsets
Interleukin-12
Natural Killer Cells
Intercellular Signaling Peptides and Proteins
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

TCR-independent activation of extrathymically developed, self antigen- specific T cells by IL-2/IL-15. / Yamada, Hisakata; Nakamura, Takahiko; Matsuzaki, Goro; Iwamoto, Yukihide; Nomoto, Kikuo.

In: Journal of Immunology, Vol. 164, No. 4, 15.02.2000, p. 1746-1752.

Research output: Contribution to journalArticle

Yamada, Hisakata ; Nakamura, Takahiko ; Matsuzaki, Goro ; Iwamoto, Yukihide ; Nomoto, Kikuo. / TCR-independent activation of extrathymically developed, self antigen- specific T cells by IL-2/IL-15. In: Journal of Immunology. 2000 ; Vol. 164, No. 4. pp. 1746-1752.
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