Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Hirofumi Tachibana, Yoshinori Fujimura, Koji Yamada

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

Original languageEnglish
Pages (from-to)383-385
Number of pages3
JournalBioFactors
Volume21
Issue number1-4
DOIs
Publication statusPublished - Jan 1 2004

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Anti-Allergic Agents
Catechin
Polyphenols
Tea
Cell membranes
Membrane Lipids
Cell Membrane
Lipids
Membrane Microdomains
IgE Receptors
Immunoglobulin E
Hypersensitivity
Down-Regulation
epigallocatechin gallate
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

Cite this

Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts : Lipid rafts mediate anti-allergic action of the catechin. / Tachibana, Hirofumi; Fujimura, Yoshinori; Yamada, Koji.

In: BioFactors, Vol. 21, No. 1-4, 01.01.2004, p. 383-385.

Research output: Contribution to journalArticle

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