Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Hirofumi Tachibana; Yoshinori Fujimura; Koji Yamada

doi:10.1002/biof.552210174

Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Hirofumi Tachibana, Yoshinori Fujimura, Koji Yamada

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

Original language	English
Pages (from-to)	383-385
Number of pages	3
Journal	BioFactors
Volume	21
Issue number	1-4
DOIs	https://doi.org/10.1002/biof.552210174
Publication status	Published - Jan 1 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Clinical Biochemistry

Access to Document

10.1002/biof.552210174

Cite this

@article{b8b8e0eee0dd4609b5069abd8372841b,

title = "Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin",

abstract = "High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.",

author = "Hirofumi Tachibana and Yoshinori Fujimura and Koji Yamada",

year = "2004",

month = jan,

day = "1",

doi = "10.1002/biof.552210174",

language = "English",

volume = "21",

pages = "383--385",

journal = "BioFactors",

issn = "0951-6433",

publisher = "Wiley-Blackwell",

number = "1-4",

}

TY - JOUR

T1 - Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts

T2 - Lipid rafts mediate anti-allergic action of the catechin

AU - Tachibana, Hirofumi

AU - Fujimura, Yoshinori

AU - Yamada, Koji

PY - 2004/1/1

Y1 - 2004/1/1

N2 - High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

AB - High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

UR - http://www.scopus.com/inward/record.url?scp=16444365479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16444365479&partnerID=8YFLogxK

U2 - 10.1002/biof.552210174

DO - 10.1002/biof.552210174

M3 - Article

C2 - 15630231

AN - SCOPUS:16444365479

VL - 21

SP - 383

EP - 385

JO - BioFactors

JF - BioFactors

SN - 0951-6433

IS - 1-4

ER -

Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this