Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Hirofumi Tachibana; Yoshinori Fujimura; Koji Yamada

doi:10.1002/biof.552210174

Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

Hirofumi Tachibana, Yoshinori Fujimura, Koji Yamada

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

Original language	English
Pages (from-to)	383-385
Number of pages	3
Journal	BioFactors
Volume	21
Issue number	1-4
DOIs	https://doi.org/10.1002/biof.552210174
Publication status	Published - Jan 1 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Clinical Biochemistry

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abstract = "High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.",

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AB - High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.

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