Abstract
High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.
Original language | English |
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Pages (from-to) | 383-385 |
Number of pages | 3 |
Journal | BioFactors |
Volume | 21 |
Issue number | 1-4 |
DOIs | |
Publication status | Published - Jan 1 2004 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Clinical Biochemistry