Abstract
High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.
| Original language | English |
|---|---|
| Pages (from-to) | 383-385 |
| Number of pages | 3 |
| Journal | BioFactors |
| Volume | 21 |
| Issue number | 1-4 |
| DOIs | |
| Publication status | Published - Jan 1 2004 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Clinical Biochemistry
Cite this
Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts : Lipid rafts mediate anti-allergic action of the catechin. / Tachibana, Hirofumi; Fujimura, Yoshinori; Yamada, Koji.
In: BioFactors, Vol. 21, No. 1-4, 01.01.2004, p. 383-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts
T2 - Lipid rafts mediate anti-allergic action of the catechin
AU - Tachibana, Hirofumi
AU - Fujimura, Yoshinori
AU - Yamada, Koji
PY - 2004/1/1
Y1 - 2004/1/1
N2 - High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.
AB - High-affinity IgE receptor FcεRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcεRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcεRI -suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcεRI expression.
UR - http://www.scopus.com/inward/record.url?scp=16444365479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16444365479&partnerID=8YFLogxK
U2 - 10.1002/biof.552210174
DO - 10.1002/biof.552210174
M3 - Article
C2 - 15630231
AN - SCOPUS:16444365479
VL - 21
SP - 383
EP - 385
JO - BioFactors
JF - BioFactors
SN - 0951-6433
IS - 1-4
ER -