Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor

T. Murata; T. Ishibashi; H. Yoshikawa; A. Khalil; H. Inomata

doi:10.1159/000267744

Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor

T. Murata, T. Ishibashi, H. Yoshikawa, A. Khalil, H. Inomata

Kyushu University Hospital

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be a possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances.

Original language	English
Pages (from-to)	330-334
Number of pages	5
Journal	Ophthalmic Research
Volume	27
Issue number	6
DOIs	https://doi.org/10.1159/000267744
Publication status	Published - Jan 1 1995

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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abstract = "The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be a possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances.",

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AU - Inomata, H.

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AB - The antiangiogenic effect of tecogalan sodium on corneal neovascularization was investigated. Tecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose-dependent manner. Since bFGF is known to have a promoting effect on corneal neovascularization, tecogalan sodium may be a possible therapeutic agent for corneal neovascularization, which can cause severe visual disturbances.

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Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor

Abstract

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