Telomerase and oral cancer

Tomoki Sumida, H. Hamakawa

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Abstract

The development of malignant neoplasms is a multistep process and it is believed that multiple genetic alterations are involved. The progression of neoplastic lesions is also characterized by reactivation of telomerase, a ribonucleoprotein complex enzyme that adds telomere repeats at the ends of chromosomes. In view of the close association between telomerase and malignancy, this molecule may prove to be a useful marker for malignancy. This review focuses on the diagnostic and therapeutic potential of telomerase. The experimental data for telomerase assays with the potential for oral cancer detection and diagnosis are also reviewed.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalOral Oncology
Volume37
Issue number4
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

Fingerprint

Mouth Neoplasms
Telomerase
Oral Diagnosis
Neoplasms
Ribonucleoproteins
Telomere
Chromosomes
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Telomerase and oral cancer. / Sumida, Tomoki; Hamakawa, H.

In: Oral Oncology, Vol. 37, No. 4, 01.01.2001, p. 333-340.

Research output: Contribution to journalShort survey

Sumida, Tomoki ; Hamakawa, H. / Telomerase and oral cancer. In: Oral Oncology. 2001 ; Vol. 37, No. 4. pp. 333-340.
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