Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

Kazunori Kanegawa, Hideki Harada, Hisashi Myouga, Yoshinori Katakura, Sanetaka Shirahata, Yuto Kamei

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We attempted to screen for telomerase inhibiting activity in vitro from a total of 304 marine algae samples which were collected from various Japan coasts by nonradioisotope telomeric repeat amplification protocol (Non-RI TRAP) assay using human leukemia MOLT-4 cells. Ten of the MeOH extracts and two of the PBS extracts from those algal samples showed telomerase inhibiting activity. In particular, the MeOH extract from a green alga, Caulerpa sertularioides strongly inhibited telomerase activity when added to MOLT-4 cell culture at a level of 1.25% (v/v), suggesting that it may be possible to develop a novel anti-cancer agent in view of its specific anti-telomeric property.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalCytotechnology
Volume33
Issue number1-3
Publication statusPublished - 2000

Fingerprint

Telomerase
Natural resources
Algae
Caulerpa
Cell culture
Amplification
Coastal zones
Assays
Chlorophyta
Japan
Leukemia
Cell Culture Techniques
In Vitro Techniques
Natural Resources
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Biotechnology
  • Clinical Biochemistry

Cite this

Kanegawa, K., Harada, H., Myouga, H., Katakura, Y., Shirahata, S., & Kamei, Y. (2000). Telomerase inhibiting activity in vitro from natural resources, marine algae extracts. Cytotechnology, 33(1-3), 221-227.

Telomerase inhibiting activity in vitro from natural resources, marine algae extracts. / Kanegawa, Kazunori; Harada, Hideki; Myouga, Hisashi; Katakura, Yoshinori; Shirahata, Sanetaka; Kamei, Yuto.

In: Cytotechnology, Vol. 33, No. 1-3, 2000, p. 221-227.

Research output: Contribution to journalArticle

Kanegawa, K, Harada, H, Myouga, H, Katakura, Y, Shirahata, S & Kamei, Y 2000, 'Telomerase inhibiting activity in vitro from natural resources, marine algae extracts', Cytotechnology, vol. 33, no. 1-3, pp. 221-227.
Kanegawa K, Harada H, Myouga H, Katakura Y, Shirahata S, Kamei Y. Telomerase inhibiting activity in vitro from natural resources, marine algae extracts. Cytotechnology. 2000;33(1-3):221-227.
Kanegawa, Kazunori ; Harada, Hideki ; Myouga, Hisashi ; Katakura, Yoshinori ; Shirahata, Sanetaka ; Kamei, Yuto. / Telomerase inhibiting activity in vitro from natural resources, marine algae extracts. In: Cytotechnology. 2000 ; Vol. 33, No. 1-3. pp. 221-227.
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