Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

Kazunori Kanegawa, Hideki Harada, Hisashi Myouga, Yoshinori Katakura, Sanetaka Shirahata, Yuto Kamei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We attempted to screen for telomerase inhibiting activity in vitro from a total of 304 marine algae samples which were collected from various Japan coasts by nonradioisotope telomeric repeat amplification protocol (Non-RI TRAP) assay using human leukemia MOLT-4 cells. Ten of the MeOH extracts and two of the PBS extracts from those algal samples showed telomerase inhibiting activity. In particular, the MeOH extract from a green alga, Caulerpa sertularioides strongly inhibited telomerase activity when added to MOLT-4 cell culture at a level of 1.25% (v/v), suggesting that it may be possible to develop a novel anti-cancer agent in view of its specific anti-telomeric property.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalCytotechnology
Volume33
Issue number1-3
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

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