Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

Original languageEnglish
Pages (from-to)15776-15787
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
Publication statusPublished - May 30 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming'. Together they form a unique fingerprint.

Cite this