Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere length of circulating leukocytes in association with age (-41.9 bp/year, p = 0.045) in contrast with controls (-18.3 kb/year, p = 0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (-16.4 bp/year, p = 0.372) in contrast with controls (-55.9 bp/year, p = 0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background lifestyle-associated diseases promoting biological aging.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalCanadian journal of physiology and pharmacology
Volume99
Issue number3
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner'. Together they form a unique fingerprint.

Cite this