Temperature compensation in circadian clock models

Gen Kurosawa, Yoh Iwasa

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Circadian clock of organisms has a free-running period that does not change much with ambient temperature. This property "temperature compensation" is studied when the rate of all reaction steps increase with temperature in the biochemical network generating the rhythm. The period becomes shorter when all the rate parameters are enhanced by the same factor. However, the period becomes longer as degradation rate of proteins and/or transcription rate of the clock gene increase (their elasticity is positive). This holds for a wide range of models, including N-variable model, and PER-TIM double oscillator model, provided that (1) branch reactions (e.g. degradation of proteins or mRNAs) are strongly saturated, and that (2) the cooperativity of transcription inhibition by nuclear proteins is not very large. A strong temperature sensitivity of degradation of PER proteins and/or temperature-sensitive alternative splicing of per gene, known for Drosophila, can be mechanisms for the temperature compensation of circadian clock.

Original languageEnglish
Pages (from-to)453-468
Number of pages16
JournalJournal of Theoretical Biology
Volume233
Issue number4
DOIs
Publication statusPublished - Apr 21 2005

Fingerprint

Temperature Compensation
Circadian Clocks
circadian rhythm
Clocks
Protein
Degradation
Temperature
Transcription
Proteolysis
protein degradation
temperature
Gene
Proteins
Alternative Splicing
Biochemical Networks
transcription (genetics)
Drosophilidae
Genes
Model
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Temperature compensation in circadian clock models. / Kurosawa, Gen; Iwasa, Yoh.

In: Journal of Theoretical Biology, Vol. 233, No. 4, 21.04.2005, p. 453-468.

Research output: Contribution to journalArticle

Kurosawa, Gen ; Iwasa, Yoh. / Temperature compensation in circadian clock models. In: Journal of Theoretical Biology. 2005 ; Vol. 233, No. 4. pp. 453-468.
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