Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Masaharu Murata, Wataru Kaku, Takahisa Anada, Yoshikuni Sato, Mizuo Maeda, Yoshiki Katayama

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

Original languageEnglish
Pages (from-to)986-987
Number of pages2
JournalChemistry Letters
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 5 2003

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Polymers
Oligodeoxyribonucleotides
DNA
Gene expression
Temperature
poly-N-isopropylacrylamide

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate. / Murata, Masaharu; Kaku, Wataru; Anada, Takahisa; Sato, Yoshikuni; Maeda, Mizuo; Katayama, Yoshiki.

In: Chemistry Letters, Vol. 32, No. 11, 05.11.2003, p. 986-987.

Research output: Contribution to journal › Article

Murata, M, Kaku, W, Anada, T, Sato, Y, Maeda, M & Katayama, Y 2003, 'Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate', Chemistry Letters, vol. 32, no. 11, pp. 986-987. https://doi.org/10.1246/cl.2003.986
Murata M, Kaku W, Anada T, Sato Y, Maeda M, Katayama Y. Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate. Chemistry Letters. 2003 Nov 5;32(11):986-987. https://doi.org/10.1246/cl.2003.986
Murata, Masaharu ; Kaku, Wataru ; Anada, Takahisa ; Sato, Yoshikuni ; Maeda, Mizuo ; Katayama, Yoshiki. / Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate. In: Chemistry Letters. 2003 ; Vol. 32, No. 11. pp. 986-987.
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