Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Masaharu Murata; Wataru Kaku; Takahisa Anada; Yoshikuni Sato; Mizuo Maeda; Yoshiki Katayama

doi:10.1246/cl.2003.986

Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Masaharu Murata, Wataru Kaku, Takahisa Anada, Yoshikuni Sato, Mizuo Maeda, Yoshiki Katayama

Department of Soft Materials Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

Original language	English
Pages (from-to)	986-987
Number of pages	2
Journal	Chemistry Letters
Volume	32
Issue number	11
DOIs	https://doi.org/10.1246/cl.2003.986
Publication status	Published - Nov 5 2003

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.2003.986

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title = "Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate",

abstract = "We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.",

author = "Masaharu Murata and Wataru Kaku and Takahisa Anada and Yoshikuni Sato and Mizuo Maeda and Yoshiki Katayama",

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T1 - Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

AU - Murata, Masaharu

AU - Kaku, Wataru

AU - Anada, Takahisa

AU - Sato, Yoshikuni

AU - Maeda, Mizuo

AU - Katayama, Yoshiki

PY - 2003/11/5

Y1 - 2003/11/5

N2 - We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

AB - We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

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JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

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ER -

Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Abstract

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