Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Masaharu Murata, Wataru Kaku, Takahisa Anada, Yoshikuni Sato, Mizuo Maeda, Yoshiki Katayama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

Original languageEnglish
Pages (from-to)986-987
Number of pages2
JournalChemistry Letters
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 5 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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