Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

Toyohiro Naito, Rerngchai Arayanarakool, Séverine Le Gac, Takao Yasui, Noritada Kaji, Manabu Tokeshi, Albert Van Den Berg, Yoshinobu Baba

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalLab on a Chip
Volume13
Issue number3
DOIs
Publication statusPublished - Feb 7 2013
Externally publishedYes

Fingerprint

Lab-On-A-Chip Devices
Polymerase chain reaction
Microfluidics
Polymers
Equipment and Supplies
Temperature
Thermoplastics
Chemical activation
Heating
Fabrication
Polymerase Chain Reaction
Hot Temperature
Pressure

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Naito, T., Arayanarakool, R., Le Gac, S., Yasui, T., Kaji, N., Tokeshi, M., ... Baba, Y. (2013). Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. Lab on a Chip, 13(3), 452-458. https://doi.org/10.1039/c2lc41030c

Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. / Naito, Toyohiro; Arayanarakool, Rerngchai; Le Gac, Séverine; Yasui, Takao; Kaji, Noritada; Tokeshi, Manabu; Van Den Berg, Albert; Baba, Yoshinobu.

In: Lab on a Chip, Vol. 13, No. 3, 07.02.2013, p. 452-458.

Research output: Contribution to journalArticle

Naito, T, Arayanarakool, R, Le Gac, S, Yasui, T, Kaji, N, Tokeshi, M, Van Den Berg, A & Baba, Y 2013, 'Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices', Lab on a Chip, vol. 13, no. 3, pp. 452-458. https://doi.org/10.1039/c2lc41030c
Naito, Toyohiro ; Arayanarakool, Rerngchai ; Le Gac, Séverine ; Yasui, Takao ; Kaji, Noritada ; Tokeshi, Manabu ; Van Den Berg, Albert ; Baba, Yoshinobu. / Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. In: Lab on a Chip. 2013 ; Vol. 13, No. 3. pp. 452-458.
@article{95e0362ff4d0419fa9c927903ad8518e,
title = "Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices",
abstract = "We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.",
author = "Toyohiro Naito and Rerngchai Arayanarakool and {Le Gac}, S{\'e}verine and Takao Yasui and Noritada Kaji and Manabu Tokeshi and {Van Den Berg}, Albert and Yoshinobu Baba",
year = "2013",
month = "2",
day = "7",
doi = "10.1039/c2lc41030c",
language = "English",
volume = "13",
pages = "452--458",
journal = "Lab on a Chip - Miniaturisation for Chemistry and Biology",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "3",

}

TY - JOUR

T1 - Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

AU - Naito, Toyohiro

AU - Arayanarakool, Rerngchai

AU - Le Gac, Séverine

AU - Yasui, Takao

AU - Kaji, Noritada

AU - Tokeshi, Manabu

AU - Van Den Berg, Albert

AU - Baba, Yoshinobu

PY - 2013/2/7

Y1 - 2013/2/7

N2 - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.

AB - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.

UR - http://www.scopus.com/inward/record.url?scp=84872087163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872087163&partnerID=8YFLogxK

U2 - 10.1039/c2lc41030c

DO - 10.1039/c2lc41030c

M3 - Article

VL - 13

SP - 452

EP - 458

JO - Lab on a Chip - Miniaturisation for Chemistry and Biology

JF - Lab on a Chip - Miniaturisation for Chemistry and Biology

SN - 1473-0197

IS - 3

ER -