Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

Toyohiro Naito; Rerngchai Arayanarakool; Séverine Le Gac; Takao Yasui; Noritada Kaji; Manabu Tokeshi; Albert Van Den Berg; Yoshinobu Baba

doi:10.1039/c2lc41030c

Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

Toyohiro Naito, Rerngchai Arayanarakool, Séverine Le Gac, Takao Yasui, Noritada Kaji, Manabu Tokeshi, Albert Van Den Berg, Yoshinobu Baba

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.

Original language	English
Pages (from-to)	452-458
Number of pages	7
Journal	Lab on a Chip
Volume	13
Issue number	3
DOIs	https://doi.org/10.1039/c2lc41030c
Publication status	Published - Feb 7 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
Biochemistry
Chemistry(all)
Biomedical Engineering

Access to Document

10.1039/c2lc41030c

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Naito, T., Arayanarakool, R., Le Gac, S., Yasui, T., Kaji, N., Tokeshi, M., Van Den Berg, A., & Baba, Y. (2013). Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. Lab on a Chip, 13(3), 452-458. https://doi.org/10.1039/c2lc41030c

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AU - Kaji, Noritada

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AU - Van Den Berg, Albert

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