Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices

Toyohiro Naito, Rerngchai Arayanarakool, Séverine Le Gac, Takao Yasui, Noritada Kaji, Manabu Tokeshi, Albert Van Den Berg, Yoshinobu Baba

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalLab on a Chip
Volume13
Issue number3
DOIs
Publication statusPublished - Feb 7 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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  • Cite this

    Naito, T., Arayanarakool, R., Le Gac, S., Yasui, T., Kaji, N., Tokeshi, M., Van Den Berg, A., & Baba, Y. (2013). Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. Lab on a Chip, 13(3), 452-458. https://doi.org/10.1039/c2lc41030c