TY - JOUR
T1 - Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices
AU - Naito, Toyohiro
AU - Arayanarakool, Rerngchai
AU - Le Gac, Séverine
AU - Yasui, Takao
AU - Kaji, Noritada
AU - Tokeshi, Manabu
AU - Van Den Berg, Albert
AU - Baba, Yoshinobu
PY - 2013/2/7
Y1 - 2013/2/7
N2 - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
AB - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
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U2 - 10.1039/c2lc41030c
DO - 10.1039/c2lc41030c
M3 - Article
C2 - 23235490
AN - SCOPUS:84872087163
VL - 13
SP - 452
EP - 458
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 3
ER -