Abstract
We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
| Original language | English |
|---|---|
| Pages (from-to) | 452-458 |
| Number of pages | 7 |
| Journal | Lab on a Chip |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 7 2013 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
Cite this
Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices. / Naito, Toyohiro; Arayanarakool, Rerngchai; Le Gac, Séverine; Yasui, Takao; Kaji, Noritada; Tokeshi, Manabu; Van Den Berg, Albert; Baba, Yoshinobu.
In: Lab on a Chip, Vol. 13, No. 3, 07.02.2013, p. 452-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices
AU - Naito, Toyohiro
AU - Arayanarakool, Rerngchai
AU - Le Gac, Séverine
AU - Yasui, Takao
AU - Kaji, Noritada
AU - Tokeshi, Manabu
AU - Van Den Berg, Albert
AU - Baba, Yoshinobu
PY - 2013/2/7
Y1 - 2013/2/7
N2 - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
AB - We present here a novel microchamber sealing valve that is self-actuated by a pressure change during the temperature change in the thermal activation of reactions. Actuation of our valve requires only the use of the same heating device as employed for the reactions. A thermoplastic UV-curable polymer is used as a device material; the polymer allows realization of the temperature-driven valve actuation as well as the fabrication of multi-layered devices. The self-actuated valve achieves effective sealing of the microchamber for the polymerase chain reaction (PCR) even at 90 °C, which is essential for developing highly parallel PCR array devices without the need for complicated peripherals to control the valve operation.
UR - http://www.scopus.com/inward/record.url?scp=84872087163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872087163&partnerID=8YFLogxK
U2 - 10.1039/c2lc41030c
DO - 10.1039/c2lc41030c
M3 - Article
VL - 13
SP - 452
EP - 458
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 3
ER -