Temperature-driven self-actuated microvalve for PCR

Toyohiro Naito; Rerngchai Arayanarakool; Noritada Kaji; Yukihiro Okamoto; Manabu Tokeshi; Séverine Le Gac; Albert Van Den Berg; Y. Baba

Temperature-driven self-actuated microvalve for PCR

Toyohiro Naito, Rerngchai Arayanarakool, Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Séverine Le Gac, Albert Van Den Berg, Y. Baba

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report here a novel chamber-sealing valve that is self-actuated by pressure change during the cyclic temperature changes in PCR processes. Actuation of our valve requirs only a heating device employed for PCR. An UV-curable polymer is used as a device material and it allowed us to realize temperature-driven valve actuation as well as to fabricate a 3D device. The self-actuated microvalve achieves the effective sealing of microchamber for PCR even at 90°C, which is essential to develop highly parallel PCR array device without any complicated actuator circuits.

Original language	English
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	248-250
Number of pages	3
Publication status	Published - Dec 1 2011
Externally published	Yes
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: Oct 2 2011 → Oct 6 2011

Publication series

Name	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume	1

Other

Other	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country	United States
City	Seattle, WA
Period	10/2/11 → 10/6/11

All Science Journal Classification (ASJC) codes

Control and Systems Engineering

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Cite this

Naito, T., Arayanarakool, R., Kaji, N., Okamoto, Y., Tokeshi, M., Gac, S. L., Van Den Berg, A., & Baba, Y. (2011). Temperature-driven self-actuated microvalve for PCR. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 248-250). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Temperature-driven self-actuated microvalve for PCR. / Naito, Toyohiro; Arayanarakool, Rerngchai; Kaji, Noritada; Okamoto, Yukihiro; Tokeshi, Manabu; Gac, Séverine Le; Van Den Berg, Albert; Baba, Y.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 248-250 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Naito, T, Arayanarakool, R, Kaji, N, Okamoto, Y, Tokeshi, M, Gac, SL, Van Den Berg, A & Baba, Y 2011, Temperature-driven self-actuated microvalve for PCR. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, vol. 1, pp. 248-250, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 10/2/11.

Naito, Toyohiro ; Arayanarakool, Rerngchai ; Kaji, Noritada ; Okamoto, Yukihiro ; Tokeshi, Manabu ; Gac, Séverine Le ; Van Den Berg, Albert ; Baba, Y. / Temperature-driven self-actuated microvalve for PCR. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. pp. 248-250 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

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abstract = "We report here a novel chamber-sealing valve that is self-actuated by pressure change during the cyclic temperature changes in PCR processes. Actuation of our valve requirs only a heating device employed for PCR. An UV-curable polymer is used as a device material and it allowed us to realize temperature-driven valve actuation as well as to fabricate a 3D device. The self-actuated microvalve achieves the effective sealing of microchamber for PCR even at 90°C, which is essential to develop highly parallel PCR array device without any complicated actuator circuits.",

author = "Toyohiro Naito and Rerngchai Arayanarakool and Noritada Kaji and Yukihiro Okamoto and Manabu Tokeshi and Gac, {S{\'e}verine Le} and {Van Den Berg}, Albert and Y. Baba",

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language = "English",

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AU - Naito, Toyohiro

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AU - Okamoto, Yukihiro

AU - Tokeshi, Manabu

AU - Gac, Séverine Le

AU - Van Den Berg, Albert

AU - Baba, Y.

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AB - We report here a novel chamber-sealing valve that is self-actuated by pressure change during the cyclic temperature changes in PCR processes. Actuation of our valve requirs only a heating device employed for PCR. An UV-curable polymer is used as a device material and it allowed us to realize temperature-driven valve actuation as well as to fabricate a 3D device. The self-actuated microvalve achieves the effective sealing of microchamber for PCR even at 90°C, which is essential to develop highly parallel PCR array device without any complicated actuator circuits.

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