Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain

Katsunori Tanaka, Sanae Shirotsuki, Takayuki Iwata, Chika Kageyama, Tsuyoshi Tahara, Satoshi Nozaki, Eric R.O. Siwu, Satoru Tamura, Shunsuke Douke, Nobutoshi Murakami, Hirotaka Onoe, Yasuyoshi Watanabe, Koichi Fukase

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.

Original languageEnglish
Pages (from-to)637-645
Number of pages9
JournalACS Chemical Biology
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 20 2012
Externally publishedYes

Fingerprint

src Homology Domains
Peptides
Artificial Receptors
Proteins
Cytotoxicity
Tumors
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine

Cite this

Tanaka, K., Shirotsuki, S., Iwata, T., Kageyama, C., Tahara, T., Nozaki, S., ... Fukase, K. (2012). Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain. ACS Chemical Biology, 7(4), 637-645. https://doi.org/10.1021/cb2003175

Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain. / Tanaka, Katsunori; Shirotsuki, Sanae; Iwata, Takayuki; Kageyama, Chika; Tahara, Tsuyoshi; Nozaki, Satoshi; Siwu, Eric R.O.; Tamura, Satoru; Douke, Shunsuke; Murakami, Nobutoshi; Onoe, Hirotaka; Watanabe, Yasuyoshi; Fukase, Koichi.

In: ACS Chemical Biology, Vol. 7, No. 4, 20.04.2012, p. 637-645.

Research output: Contribution to journalReview article

Tanaka, K, Shirotsuki, S, Iwata, T, Kageyama, C, Tahara, T, Nozaki, S, Siwu, ERO, Tamura, S, Douke, S, Murakami, N, Onoe, H, Watanabe, Y & Fukase, K 2012, 'Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain', ACS Chemical Biology, vol. 7, no. 4, pp. 637-645. https://doi.org/10.1021/cb2003175
Tanaka, Katsunori ; Shirotsuki, Sanae ; Iwata, Takayuki ; Kageyama, Chika ; Tahara, Tsuyoshi ; Nozaki, Satoshi ; Siwu, Eric R.O. ; Tamura, Satoru ; Douke, Shunsuke ; Murakami, Nobutoshi ; Onoe, Hirotaka ; Watanabe, Yasuyoshi ; Fukase, Koichi. / Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain. In: ACS Chemical Biology. 2012 ; Vol. 7, No. 4. pp. 637-645.
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