Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: Nationwide survey results over 30 years

M. Osoegawa, Jun-Ichi Kira, T. Fukazawa, K. Fujihara, S. Kikuchi, M. Matsui, T. Kohriyama, G. Sobue, T. Yamamura, Y. Itoyama, T. Saida, K. Sakata, H. Ochi, T. Matsuoka, Yoshigoro Kuroiwa, Akihiro Igata, Hiroshi Nishitani, Susumu Chiba, Yoshitaka Fujii, Susumu FurukawaHideo Hara, Toshirou Hara, Kinya Hisanaga, Shu Ichi Ikeda, Shuji Izumo, Ryuji Kaji, Takashi Kanda, Shosei Koh, Susumu Kusunoki, Satoshi Kuwabara, Hidenori Matsuo, Hidehiro Mizusawa, Tatsufumi Nakamura, Kyoichi Nomura, Mieko Ogino, Yoshiro Ohara, Mitsuhiro Osame, Kohei Ota, Jun Shimizu, Akio Suzumura, Takeshi Tabira, Keiko Tanaka, Masami Tanaka, Makoto Yoneda, Hiroaki Yoshikawa, Nobuhiro Yuki

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Abstract

Background: There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as optic-spinal (OSMS) and conventional (CMS) forms. In Japan, four nationwide surveys of MS have been conducted. The first three were in 1972, 1982, and 1989, and we performed the fourth in 2004. Results: The recent survey showed six main findings as follows: (1) a four-fold increase in the estimated number of clinically definite patients with MS in 2003 (9900; crude MS prevalence, 7.7/100,000) compared with 1972; (2) a shift in the peak age at onset from early 30s in 1989 to early 20s in 2003; (3) a successive proportional decrease in optic-spinal involvement in clinically definite patients with MS; (4) a significant north-south gradient for the CMS/OSMS ratio; (5) after subdivision of the mainland (30-45° North) into northern and southern parts at 37°N, northern-born northern residents (northern patients) showed a significantly higher CMS/OSMS ratio and higher frequency of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) than southern-born southern residents (southern patients); (6) among northern patients, the absolute numbers of patients with CMS and those with Barkhof brain lesions rapidly increased with advancing birth year. Conclusions: These findings suggest that MS phenotypes are drastically altered by environmental factors, such as latitude and "Westernization".

Original languageEnglish
Pages (from-to)159-173
Number of pages15
JournalMultiple Sclerosis
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 9 2009

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Multiple Sclerosis
Phenotype
Brain
Age of Onset
Surveys and Questionnaires
Japan
Parturition

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : Nationwide survey results over 30 years. / Osoegawa, M.; Kira, Jun-Ichi; Fukazawa, T.; Fujihara, K.; Kikuchi, S.; Matsui, M.; Kohriyama, T.; Sobue, G.; Yamamura, T.; Itoyama, Y.; Saida, T.; Sakata, K.; Ochi, H.; Matsuoka, T.; Kuroiwa, Yoshigoro; Igata, Akihiro; Nishitani, Hiroshi; Chiba, Susumu; Fujii, Yoshitaka; Furukawa, Susumu; Hara, Hideo; Hara, Toshirou; Hisanaga, Kinya; Ikeda, Shu Ichi; Izumo, Shuji; Kaji, Ryuji; Kanda, Takashi; Koh, Shosei; Kusunoki, Susumu; Kuwabara, Satoshi; Matsuo, Hidenori; Mizusawa, Hidehiro; Nakamura, Tatsufumi; Nomura, Kyoichi; Ogino, Mieko; Ohara, Yoshiro; Osame, Mitsuhiro; Ota, Kohei; Shimizu, Jun; Suzumura, Akio; Tabira, Takeshi; Tanaka, Keiko; Tanaka, Masami; Yoneda, Makoto; Yoshikawa, Hiroaki; Yuki, Nobuhiro.

In: Multiple Sclerosis, Vol. 15, No. 2, 09.02.2009, p. 159-173.

Research output: Contribution to journalArticle

Osoegawa, M, Kira, J-I, Fukazawa, T, Fujihara, K, Kikuchi, S, Matsui, M, Kohriyama, T, Sobue, G, Yamamura, T, Itoyama, Y, Saida, T, Sakata, K, Ochi, H, Matsuoka, T, Kuroiwa, Y, Igata, A, Nishitani, H, Chiba, S, Fujii, Y, Furukawa, S, Hara, H, Hara, T, Hisanaga, K, Ikeda, SI, Izumo, S, Kaji, R, Kanda, T, Koh, S, Kusunoki, S, Kuwabara, S, Matsuo, H, Mizusawa, H, Nakamura, T, Nomura, K, Ogino, M, Ohara, Y, Osame, M, Ota, K, Shimizu, J, Suzumura, A, Tabira, T, Tanaka, K, Tanaka, M, Yoneda, M, Yoshikawa, H & Yuki, N 2009, 'Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: Nationwide survey results over 30 years', Multiple Sclerosis, vol. 15, no. 2, pp. 159-173. https://doi.org/10.1177/1352458508098372
Osoegawa, M. ; Kira, Jun-Ichi ; Fukazawa, T. ; Fujihara, K. ; Kikuchi, S. ; Matsui, M. ; Kohriyama, T. ; Sobue, G. ; Yamamura, T. ; Itoyama, Y. ; Saida, T. ; Sakata, K. ; Ochi, H. ; Matsuoka, T. ; Kuroiwa, Yoshigoro ; Igata, Akihiro ; Nishitani, Hiroshi ; Chiba, Susumu ; Fujii, Yoshitaka ; Furukawa, Susumu ; Hara, Hideo ; Hara, Toshirou ; Hisanaga, Kinya ; Ikeda, Shu Ichi ; Izumo, Shuji ; Kaji, Ryuji ; Kanda, Takashi ; Koh, Shosei ; Kusunoki, Susumu ; Kuwabara, Satoshi ; Matsuo, Hidenori ; Mizusawa, Hidehiro ; Nakamura, Tatsufumi ; Nomura, Kyoichi ; Ogino, Mieko ; Ohara, Yoshiro ; Osame, Mitsuhiro ; Ota, Kohei ; Shimizu, Jun ; Suzumura, Akio ; Tabira, Takeshi ; Tanaka, Keiko ; Tanaka, Masami ; Yoneda, Makoto ; Yoshikawa, Hiroaki ; Yuki, Nobuhiro. / Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : Nationwide survey results over 30 years. In: Multiple Sclerosis. 2009 ; Vol. 15, No. 2. pp. 159-173.
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title = "Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: Nationwide survey results over 30 years",
abstract = "Background: There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as optic-spinal (OSMS) and conventional (CMS) forms. In Japan, four nationwide surveys of MS have been conducted. The first three were in 1972, 1982, and 1989, and we performed the fourth in 2004. Results: The recent survey showed six main findings as follows: (1) a four-fold increase in the estimated number of clinically definite patients with MS in 2003 (9900; crude MS prevalence, 7.7/100,000) compared with 1972; (2) a shift in the peak age at onset from early 30s in 1989 to early 20s in 2003; (3) a successive proportional decrease in optic-spinal involvement in clinically definite patients with MS; (4) a significant north-south gradient for the CMS/OSMS ratio; (5) after subdivision of the mainland (30-45° North) into northern and southern parts at 37°N, northern-born northern residents (northern patients) showed a significantly higher CMS/OSMS ratio and higher frequency of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) than southern-born southern residents (southern patients); (6) among northern patients, the absolute numbers of patients with CMS and those with Barkhof brain lesions rapidly increased with advancing birth year. Conclusions: These findings suggest that MS phenotypes are drastically altered by environmental factors, such as latitude and {"}Westernization{"}.",
author = "M. Osoegawa and Jun-Ichi Kira and T. Fukazawa and K. Fujihara and S. Kikuchi and M. Matsui and T. Kohriyama and G. Sobue and T. Yamamura and Y. Itoyama and T. Saida and K. Sakata and H. Ochi and T. Matsuoka and Yoshigoro Kuroiwa and Akihiro Igata and Hiroshi Nishitani and Susumu Chiba and Yoshitaka Fujii and Susumu Furukawa and Hideo Hara and Toshirou Hara and Kinya Hisanaga and Ikeda, {Shu Ichi} and Shuji Izumo and Ryuji Kaji and Takashi Kanda and Shosei Koh and Susumu Kusunoki and Satoshi Kuwabara and Hidenori Matsuo and Hidehiro Mizusawa and Tatsufumi Nakamura and Kyoichi Nomura and Mieko Ogino and Yoshiro Ohara and Mitsuhiro Osame and Kohei Ota and Jun Shimizu and Akio Suzumura and Takeshi Tabira and Keiko Tanaka and Masami Tanaka and Makoto Yoneda and Hiroaki Yoshikawa and Nobuhiro Yuki",
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TY - JOUR

T1 - Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese

T2 - Nationwide survey results over 30 years

AU - Osoegawa, M.

AU - Kira, Jun-Ichi

AU - Fukazawa, T.

AU - Fujihara, K.

AU - Kikuchi, S.

AU - Matsui, M.

AU - Kohriyama, T.

AU - Sobue, G.

AU - Yamamura, T.

AU - Itoyama, Y.

AU - Saida, T.

AU - Sakata, K.

AU - Ochi, H.

AU - Matsuoka, T.

AU - Kuroiwa, Yoshigoro

AU - Igata, Akihiro

AU - Nishitani, Hiroshi

AU - Chiba, Susumu

AU - Fujii, Yoshitaka

AU - Furukawa, Susumu

AU - Hara, Hideo

AU - Hara, Toshirou

AU - Hisanaga, Kinya

AU - Ikeda, Shu Ichi

AU - Izumo, Shuji

AU - Kaji, Ryuji

AU - Kanda, Takashi

AU - Koh, Shosei

AU - Kusunoki, Susumu

AU - Kuwabara, Satoshi

AU - Matsuo, Hidenori

AU - Mizusawa, Hidehiro

AU - Nakamura, Tatsufumi

AU - Nomura, Kyoichi

AU - Ogino, Mieko

AU - Ohara, Yoshiro

AU - Osame, Mitsuhiro

AU - Ota, Kohei

AU - Shimizu, Jun

AU - Suzumura, Akio

AU - Tabira, Takeshi

AU - Tanaka, Keiko

AU - Tanaka, Masami

AU - Yoneda, Makoto

AU - Yoshikawa, Hiroaki

AU - Yuki, Nobuhiro

PY - 2009/2/9

Y1 - 2009/2/9

N2 - Background: There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as optic-spinal (OSMS) and conventional (CMS) forms. In Japan, four nationwide surveys of MS have been conducted. The first three were in 1972, 1982, and 1989, and we performed the fourth in 2004. Results: The recent survey showed six main findings as follows: (1) a four-fold increase in the estimated number of clinically definite patients with MS in 2003 (9900; crude MS prevalence, 7.7/100,000) compared with 1972; (2) a shift in the peak age at onset from early 30s in 1989 to early 20s in 2003; (3) a successive proportional decrease in optic-spinal involvement in clinically definite patients with MS; (4) a significant north-south gradient for the CMS/OSMS ratio; (5) after subdivision of the mainland (30-45° North) into northern and southern parts at 37°N, northern-born northern residents (northern patients) showed a significantly higher CMS/OSMS ratio and higher frequency of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) than southern-born southern residents (southern patients); (6) among northern patients, the absolute numbers of patients with CMS and those with Barkhof brain lesions rapidly increased with advancing birth year. Conclusions: These findings suggest that MS phenotypes are drastically altered by environmental factors, such as latitude and "Westernization".

AB - Background: There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as optic-spinal (OSMS) and conventional (CMS) forms. In Japan, four nationwide surveys of MS have been conducted. The first three were in 1972, 1982, and 1989, and we performed the fourth in 2004. Results: The recent survey showed six main findings as follows: (1) a four-fold increase in the estimated number of clinically definite patients with MS in 2003 (9900; crude MS prevalence, 7.7/100,000) compared with 1972; (2) a shift in the peak age at onset from early 30s in 1989 to early 20s in 2003; (3) a successive proportional decrease in optic-spinal involvement in clinically definite patients with MS; (4) a significant north-south gradient for the CMS/OSMS ratio; (5) after subdivision of the mainland (30-45° North) into northern and southern parts at 37°N, northern-born northern residents (northern patients) showed a significantly higher CMS/OSMS ratio and higher frequency of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) than southern-born southern residents (southern patients); (6) among northern patients, the absolute numbers of patients with CMS and those with Barkhof brain lesions rapidly increased with advancing birth year. Conclusions: These findings suggest that MS phenotypes are drastically altered by environmental factors, such as latitude and "Westernization".

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