Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse: A preliminary study

Mizuki Ninomiya, Ken Shirabe, Hideki Ijichi, Takeo Toshima, Noboru Harada, Hideaki Uchiyama, Akinobu Taketomi, Tomoharu Yoshizumi, Yoshihiko Maehara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation. Methods: Nineteen living donors who received right lobectomy (small remnant liver [SRL] group; n=7) or extended left and caudate lobectomy (large remnant liver [LRL] group; n=12) were enrolled. They underwent measurement of liver and spleen VTTQ before and after donor surgery. Results: Virtual touch tissue quantification of the remnant liver increased postoperatively until postoperative day (POD) 3-5, and the values in the SRL group were significantly higher than those in the LRL group at POD 3-9. The values of the spleen also increased after donor surgery and the values in the SRL group were significantly higher than those in the LRL group at POD 3-14. A significant positive correlation between postoperative maximum value of VTTQ and postoperative maximum total bilirubin levels was observed. In liver transplant recipients, there was a significant positive correlation between preoperative spleen VTTQ and the corresponding actual portal venous pressure that was measured at the time of transplant surgery. Conclusion: Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration.

Original languageEnglish
Pages (from-to)579-586
Number of pages8
JournalHepatology Research
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

Fingerprint

Hepatectomy
Acoustics
Spleen
Tissue Donors
Radiation
Liver
Touch
Living Donors
Elasticity Imaging Techniques
Portal Pressure
Liver Regeneration
Bilirubin

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

Cite this

Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse : A preliminary study. / Ninomiya, Mizuki; Shirabe, Ken; Ijichi, Hideki; Toshima, Takeo; Harada, Noboru; Uchiyama, Hideaki; Taketomi, Akinobu; Yoshizumi, Tomoharu; Maehara, Yoshihiko.

In: Hepatology Research, Vol. 41, No. 6, 01.06.2011, p. 579-586.

Research output: Contribution to journalArticle

Ninomiya, Mizuki ; Shirabe, Ken ; Ijichi, Hideki ; Toshima, Takeo ; Harada, Noboru ; Uchiyama, Hideaki ; Taketomi, Akinobu ; Yoshizumi, Tomoharu ; Maehara, Yoshihiko. / Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse : A preliminary study. In: Hepatology Research. 2011 ; Vol. 41, No. 6. pp. 579-586.
@article{bb7f813990f24d398cbf36f2fb190f9e,
title = "Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse: A preliminary study",
abstract = "Aim: Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation. Methods: Nineteen living donors who received right lobectomy (small remnant liver [SRL] group; n=7) or extended left and caudate lobectomy (large remnant liver [LRL] group; n=12) were enrolled. They underwent measurement of liver and spleen VTTQ before and after donor surgery. Results: Virtual touch tissue quantification of the remnant liver increased postoperatively until postoperative day (POD) 3-5, and the values in the SRL group were significantly higher than those in the LRL group at POD 3-9. The values of the spleen also increased after donor surgery and the values in the SRL group were significantly higher than those in the LRL group at POD 3-14. A significant positive correlation between postoperative maximum value of VTTQ and postoperative maximum total bilirubin levels was observed. In liver transplant recipients, there was a significant positive correlation between preoperative spleen VTTQ and the corresponding actual portal venous pressure that was measured at the time of transplant surgery. Conclusion: Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration.",
author = "Mizuki Ninomiya and Ken Shirabe and Hideki Ijichi and Takeo Toshima and Noboru Harada and Hideaki Uchiyama and Akinobu Taketomi and Tomoharu Yoshizumi and Yoshihiko Maehara",
year = "2011",
month = "6",
day = "1",
doi = "10.1111/j.1872-034X.2011.00809.x",
language = "English",
volume = "41",
pages = "579--586",
journal = "Hepatology Research",
issn = "1386-6346",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Temporal changes in the stiffness of the remnant liver and spleen after donor hepatectomy as assessed by acoustic radiation force impulse

T2 - A preliminary study

AU - Ninomiya, Mizuki

AU - Shirabe, Ken

AU - Ijichi, Hideki

AU - Toshima, Takeo

AU - Harada, Noboru

AU - Uchiyama, Hideaki

AU - Taketomi, Akinobu

AU - Yoshizumi, Tomoharu

AU - Maehara, Yoshihiko

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Aim: Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation. Methods: Nineteen living donors who received right lobectomy (small remnant liver [SRL] group; n=7) or extended left and caudate lobectomy (large remnant liver [LRL] group; n=12) were enrolled. They underwent measurement of liver and spleen VTTQ before and after donor surgery. Results: Virtual touch tissue quantification of the remnant liver increased postoperatively until postoperative day (POD) 3-5, and the values in the SRL group were significantly higher than those in the LRL group at POD 3-9. The values of the spleen also increased after donor surgery and the values in the SRL group were significantly higher than those in the LRL group at POD 3-14. A significant positive correlation between postoperative maximum value of VTTQ and postoperative maximum total bilirubin levels was observed. In liver transplant recipients, there was a significant positive correlation between preoperative spleen VTTQ and the corresponding actual portal venous pressure that was measured at the time of transplant surgery. Conclusion: Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration.

AB - Aim: Virtual touch tissue quantification (VTTQ) is an implementation of ultrasound acoustic radiation force impulse imaging that provides numerical measurements of tissue stiffness. We have evaluated the temporal changes of the remnant liver and spleen after living donor hepatectomy with special reference to the differences between right and left liver donation. Methods: Nineteen living donors who received right lobectomy (small remnant liver [SRL] group; n=7) or extended left and caudate lobectomy (large remnant liver [LRL] group; n=12) were enrolled. They underwent measurement of liver and spleen VTTQ before and after donor surgery. Results: Virtual touch tissue quantification of the remnant liver increased postoperatively until postoperative day (POD) 3-5, and the values in the SRL group were significantly higher than those in the LRL group at POD 3-9. The values of the spleen also increased after donor surgery and the values in the SRL group were significantly higher than those in the LRL group at POD 3-14. A significant positive correlation between postoperative maximum value of VTTQ and postoperative maximum total bilirubin levels was observed. In liver transplant recipients, there was a significant positive correlation between preoperative spleen VTTQ and the corresponding actual portal venous pressure that was measured at the time of transplant surgery. Conclusion: Stiffness of the remaining liver and spleen in the smaller remnant liver group became harder than that in the larger remnant liver group. Perioperative measurement of liver and spleen VTTQ seems to be a useful means for assessing the physiology of liver regeneration.

UR - http://www.scopus.com/inward/record.url?scp=79957567941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957567941&partnerID=8YFLogxK

U2 - 10.1111/j.1872-034X.2011.00809.x

DO - 10.1111/j.1872-034X.2011.00809.x

M3 - Article

C2 - 21561532

AN - SCOPUS:79957567941

VL - 41

SP - 579

EP - 586

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 6

ER -