Temporal trends in sudden unexpected death in a general population: The hisayama study

Masaharu Nagata, Toshiharu Ninomiya, Yasufumi Doi, Jun Hata, Fumie Ikeda, Naoko Mukai, Kazuhiko Tsuruya, Yoshinao Oda, Takanari Kitazono, Yutaka Kiyohara

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Abstract

Background Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited. Methods Among a total of 1934 residents aged 20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5%) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours. Results The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1% in 1962-1973, 13.4% in 1974-1985, 15.0% in 1986-1997, and 14.6% in 1998-2009; P for trend = .80). Regarding causes of death, the prevalence of SUD from stroke significantly declined with time (8.0%, 5.0%, 2.3%, and 2.1%, respectively; P for trend>.001), whereas significant increments were observed in the prevalence of SUD from heart disease (4.0%, 6.2%, 8.6%, and 9.7%; P for trend = .02) and from aortic aneurysm and dissection (0.2%, 1.2%, 2.9%, and 2.8%; P for trend = .01). In particular, the prevalence of ischemic heart disease increased 3-fold from 2.1% in 1962-1973 to 6.6% in 1998-2009 (P = .04). Reflecting the increment of ischemic heart disease, SUD within 1 hour increased significantly from 2.5% to 7.6% during this period (P = .01). Conclusions The trend in the prevalence of SUD was stable across a half century in a general Japanese population. Despite the decrement in the prevalence of SUD from stroke, that from heart disease, especially ischemic heart disease, increased significantly with time. (Am Heart J 2013;165:932-938.e1.).

Original languageEnglish
Pages (from-to)932-938.e1
JournalAmerican heart journal
Volume165
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Sudden Death
Population
Myocardial Ischemia
Autopsy
Cause of Death
Heart Diseases
Stroke
Aortic Aneurysm
Dissection
Japan

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Temporal trends in sudden unexpected death in a general population : The hisayama study. / Nagata, Masaharu; Ninomiya, Toshiharu; Doi, Yasufumi; Hata, Jun; Ikeda, Fumie; Mukai, Naoko; Tsuruya, Kazuhiko; Oda, Yoshinao; Kitazono, Takanari; Kiyohara, Yutaka.

In: American heart journal, Vol. 165, No. 6, 06.2013, p. 932-938.e1.

Research output: Contribution to journalArticle

Nagata, Masaharu ; Ninomiya, Toshiharu ; Doi, Yasufumi ; Hata, Jun ; Ikeda, Fumie ; Mukai, Naoko ; Tsuruya, Kazuhiko ; Oda, Yoshinao ; Kitazono, Takanari ; Kiyohara, Yutaka. / Temporal trends in sudden unexpected death in a general population : The hisayama study. In: American heart journal. 2013 ; Vol. 165, No. 6. pp. 932-938.e1.
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title = "Temporal trends in sudden unexpected death in a general population: The hisayama study",
abstract = "Background Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited. Methods Among a total of 1934 residents aged 20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5{\%}) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours. Results The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1{\%} in 1962-1973, 13.4{\%} in 1974-1985, 15.0{\%} in 1986-1997, and 14.6{\%} in 1998-2009; P for trend = .80). Regarding causes of death, the prevalence of SUD from stroke significantly declined with time (8.0{\%}, 5.0{\%}, 2.3{\%}, and 2.1{\%}, respectively; P for trend>.001), whereas significant increments were observed in the prevalence of SUD from heart disease (4.0{\%}, 6.2{\%}, 8.6{\%}, and 9.7{\%}; P for trend = .02) and from aortic aneurysm and dissection (0.2{\%}, 1.2{\%}, 2.9{\%}, and 2.8{\%}; P for trend = .01). In particular, the prevalence of ischemic heart disease increased 3-fold from 2.1{\%} in 1962-1973 to 6.6{\%} in 1998-2009 (P = .04). Reflecting the increment of ischemic heart disease, SUD within 1 hour increased significantly from 2.5{\%} to 7.6{\%} during this period (P = .01). Conclusions The trend in the prevalence of SUD was stable across a half century in a general Japanese population. Despite the decrement in the prevalence of SUD from stroke, that from heart disease, especially ischemic heart disease, increased significantly with time. (Am Heart J 2013;165:932-938.e1.).",
author = "Masaharu Nagata and Toshiharu Ninomiya and Yasufumi Doi and Jun Hata and Fumie Ikeda and Naoko Mukai and Kazuhiko Tsuruya and Yoshinao Oda and Takanari Kitazono and Yutaka Kiyohara",
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T1 - Temporal trends in sudden unexpected death in a general population

T2 - The hisayama study

AU - Nagata, Masaharu

AU - Ninomiya, Toshiharu

AU - Doi, Yasufumi

AU - Hata, Jun

AU - Ikeda, Fumie

AU - Mukai, Naoko

AU - Tsuruya, Kazuhiko

AU - Oda, Yoshinao

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

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N2 - Background Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited. Methods Among a total of 1934 residents aged 20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5%) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours. Results The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1% in 1962-1973, 13.4% in 1974-1985, 15.0% in 1986-1997, and 14.6% in 1998-2009; P for trend = .80). Regarding causes of death, the prevalence of SUD from stroke significantly declined with time (8.0%, 5.0%, 2.3%, and 2.1%, respectively; P for trend>.001), whereas significant increments were observed in the prevalence of SUD from heart disease (4.0%, 6.2%, 8.6%, and 9.7%; P for trend = .02) and from aortic aneurysm and dissection (0.2%, 1.2%, 2.9%, and 2.8%; P for trend = .01). In particular, the prevalence of ischemic heart disease increased 3-fold from 2.1% in 1962-1973 to 6.6% in 1998-2009 (P = .04). Reflecting the increment of ischemic heart disease, SUD within 1 hour increased significantly from 2.5% to 7.6% during this period (P = .01). Conclusions The trend in the prevalence of SUD was stable across a half century in a general Japanese population. Despite the decrement in the prevalence of SUD from stroke, that from heart disease, especially ischemic heart disease, increased significantly with time. (Am Heart J 2013;165:932-938.e1.).

AB - Background Studies addressing the temporal trends in the prevalence of sudden unexpected death (SUD) and its underlying causes in the general population are limited. Methods Among a total of 1934 residents aged 20 years of the town of Hisayama, Japan, who died of endogenous causes of death and underwent autopsy examination (autopsy rate 78.5%) from 1962 to 2009, 204 were determined to be cases of SUD within 24 hours. Results The trend in the age- and sex-adjusted prevalence of SUD among all autopsy subjects was stable over four 12-year periods (13.1% in 1962-1973, 13.4% in 1974-1985, 15.0% in 1986-1997, and 14.6% in 1998-2009; P for trend = .80). Regarding causes of death, the prevalence of SUD from stroke significantly declined with time (8.0%, 5.0%, 2.3%, and 2.1%, respectively; P for trend>.001), whereas significant increments were observed in the prevalence of SUD from heart disease (4.0%, 6.2%, 8.6%, and 9.7%; P for trend = .02) and from aortic aneurysm and dissection (0.2%, 1.2%, 2.9%, and 2.8%; P for trend = .01). In particular, the prevalence of ischemic heart disease increased 3-fold from 2.1% in 1962-1973 to 6.6% in 1998-2009 (P = .04). Reflecting the increment of ischemic heart disease, SUD within 1 hour increased significantly from 2.5% to 7.6% during this period (P = .01). Conclusions The trend in the prevalence of SUD was stable across a half century in a general Japanese population. Despite the decrement in the prevalence of SUD from stroke, that from heart disease, especially ischemic heart disease, increased significantly with time. (Am Heart J 2013;165:932-938.e1.).

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