Abstract
New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.
| Original language | English |
|---|---|
| Pages (from-to) | 4595-4598 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 35 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - Jun 27 1994 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Kawata, S., Oishi, T., & Hirama, M. (1994). Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate. Tetrahedron Letters, 35(26), 4595-4598. https://doi.org/10.1016/S0040-4039(00)60739-6