Abstract
New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.
| Original language | English |
|---|---|
| Pages (from-to) | 4595-4598 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 35 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - Jun 27 1994 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate. / Kawata, Shinji; Oishi, Tohru; Hirama, Masahiro.
In: Tetrahedron Letters, Vol. 35, No. 26, 27.06.1994, p. 4595-4598.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate
AU - Kawata, Shinji
AU - Oishi, Tohru
AU - Hirama, Masahiro
PY - 1994/6/27
Y1 - 1994/6/27
N2 - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.
AB - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.
UR - http://www.scopus.com/inward/record.url?scp=0028272319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028272319&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(00)60739-6
DO - 10.1016/S0040-4039(00)60739-6
M3 - Article
AN - SCOPUS:0028272319
VL - 35
SP - 4595
EP - 4598
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 26
ER -