Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Shinji Kawata, Tohru Oishi, Masahiro Hirama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

Original languageEnglish
Pages (from-to)4595-4598
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number26
DOIs
Publication statusPublished - Jun 27 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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