Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Shinji Kawata; Tohru Oishi; Masahiro Hirama

doi:10.1016/S0040-4039(00)60739-6

Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Shinji Kawata, Tohru Oishi, Masahiro Hirama

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

Original language	English
Pages (from-to)	4595-4598
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60739-6
Publication status	Published - Jun 27 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)60739-6

Cite this

@article{09c81b554108453783343cbae3daa289,

title = "Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate",

abstract = "New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.",

author = "Shinji Kawata and Tohru Oishi and Masahiro Hirama",

year = "1994",

month = jun,

day = "27",

doi = "10.1016/S0040-4039(00)60739-6",

language = "English",

volume = "35",

pages = "4595--4598",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "26",

}

TY - JOUR

T1 - Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

AU - Kawata, Shinji

AU - Oishi, Tohru

AU - Hirama, Masahiro

PY - 1994/6/27

Y1 - 1994/6/27

N2 - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

AB - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

UR - http://www.scopus.com/inward/record.url?scp=0028272319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028272319&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)60739-6

DO - 10.1016/S0040-4039(00)60739-6

M3 - Article

AN - SCOPUS:0028272319

VL - 35

SP - 4595

EP - 4598

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -

Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this