Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Shinji Kawata; Tohru Oishi; Masahiro Hirama

doi:10.1016/S0040-4039(00)60739-6

Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Shinji Kawata, Tohru Oishi, Masahiro Hirama

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

Original language	English
Pages (from-to)	4595-4598
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60739-6
Publication status	Published - Jun 27 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)60739-6

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title = "Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate",

abstract = "New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.",

author = "Shinji Kawata and Tohru Oishi and Masahiro Hirama",

note = "Funding Information: This work was financially supportedb y the Ministry of Education,S cience,a nd Culture, Japan and by the T&da and Fujisawa Science Foundations.",

year = "1994",

month = jun,

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doi = "10.1016/S0040-4039(00)60739-6",

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journal = "Tetrahedron Letters",

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T1 - Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

AU - Kawata, Shinji

AU - Oishi, Tohru

AU - Hirama, Masahiro

N1 - Funding Information: This work was financially supportedb y the Ministry of Education,S cience,a nd Culture, Japan and by the T&da and Fujisawa Science Foundations.

PY - 1994/6/27

Y1 - 1994/6/27

N2 - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

AB - New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.

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U2 - 10.1016/S0040-4039(00)60739-6

DO - 10.1016/S0040-4039(00)60739-6

M3 - Article

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EP - 4598

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -

Ten-membered neocarzinostatin chromophore analogs leading to σ,σ-biradical via a cumulene intermediate

Abstract

All Science Journal Classification (ASJC) codes

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