Abstract
New neocarzinostatin chromophore analogs of 10-membered ring are synthesized. Generation of σ,σ-biradical via a cumulene intermediate has been demonstrated. The DNA-cleaving activity of the hybrid 4 is found to be 50-fold more potent than 1.
Original language | English |
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Pages (from-to) | 4595-4598 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 35 |
Issue number | 26 |
DOIs | |
Publication status | Published - Jun 27 1994 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry