Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Minoru Omura, Miyuki Hirata, Akiyo Tanaka, Mangen Zhao, Yuji Makita, Naohide Inoue, Kaoru Gotoh, Noburu Ishinishi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalToxicology Letters
Volume89
Issue number2
DOIs
Publication statusPublished - Dec 16 1996

All Science Journal Classification (ASJC) codes

  • Toxicology

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