Testosterone/dihydrotestosterone

Yukiko Ogino; Shinichi Miyagawa; Taisen Iguchi

doi:10.1016/B978-0-12-820649-2.00253-9

Testosterone/dihydrotestosterone

Yukiko Ogino, Shinichi Miyagawa, Taisen Iguchi

Attached Promotive Center for International Education and Research of Agriculture

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Androgens are critical steroid hormones that regulate male sexual development and differentiation, including the formation of the reproductive system and the maintenance of its function. Androgens are also essential in muscle development and psychosexual behavior. Testosterone and dihydrotestosterone act as the predominant androgens in mammals. Androgens mediate their effects through the androgen receptor (AR), a member of the nuclear receptor superfamily. Liganded AR is translocated from the cytoplasm to the nucleus and regulates the transcription of androgen-responsive genes. Mutations in the AR result in diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy’s disease, and infertility.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	917-920
Number of pages	4
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00253-9
Publication status	Published - Jan 1 2021

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-820649-2.00253-9

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AU - Miyagawa, Shinichi

AU - Iguchi, Taisen

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N2 - Androgens are critical steroid hormones that regulate male sexual development and differentiation, including the formation of the reproductive system and the maintenance of its function. Androgens are also essential in muscle development and psychosexual behavior. Testosterone and dihydrotestosterone act as the predominant androgens in mammals. Androgens mediate their effects through the androgen receptor (AR), a member of the nuclear receptor superfamily. Liganded AR is translocated from the cytoplasm to the nucleus and regulates the transcription of androgen-responsive genes. Mutations in the AR result in diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy’s disease, and infertility.

AB - Androgens are critical steroid hormones that regulate male sexual development and differentiation, including the formation of the reproductive system and the maintenance of its function. Androgens are also essential in muscle development and psychosexual behavior. Testosterone and dihydrotestosterone act as the predominant androgens in mammals. Androgens mediate their effects through the androgen receptor (AR), a member of the nuclear receptor superfamily. Liganded AR is translocated from the cytoplasm to the nucleus and regulates the transcription of androgen-responsive genes. Mutations in the AR result in diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy’s disease, and infertility.

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SP - 917

EP - 920

BT - Handbook of Hormones

PB - Elsevier

ER -

Testosterone/dihydrotestosterone

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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