Th subset balance in lupus nephritis

Katsuhisa Miyake, Mitsuteru Akahoshi, Hitoshi Nakashima

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of systemic lupus nephritis (SLE). This pathogenetic mechanism in each histologically different type of lupus nephritis (LN) remains unclear. Although SLE is suggested to be a Th2-driven disease, elevation of both Th1 and Th2 cytokines occurs in both humans and mice, suggesting that SLE is a complex disease driven by different lymphocyte subsets with high heterogeneity of clinical manifestations and organ involvement. Recent findings in LN elucidate an essential role for the Th1, IL-17 producing T cells and Th17 cells in the development of diffuse proliferative lupus nephritis (DPLN), and Th2 cytokine in that of membranous lupus nephritis (MLN). These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of LN.

Original languageEnglish
Article number980286
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
Publication statusPublished - Nov 24 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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