Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes

K. Hiromatsu, H. Nishimura, K. Kimura, Y. Aoki, J. Usami, N. Kobayashi, M. Makino, Y. Yoshikai

    Research output: Contribution to journalArticle

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    Abstract

    We examined the host defence mechanism against infection with Listeria monocytogenes, a facultative intracellular bacterium, in mice with murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukaemia virus (MuLv) infection. Although LP-BM5 MuLV infection in C57BL16 mice leads to a stage of immunodeficiency characterized by severe compromise of cell-mediated immunity, the mice with established MAIDS infected with LP-BM5 8 weeks previously, showed resistance to an intraperitoneal infection with Listeria monocytogenes. These MAIDS mice also showed resistance to a lethal dose of secondary listerial challenge, while the delayed-type hypersensitivity response to heat-killed Listeria (HKL) was severely impaired in MAIDS mice. The resistance of MAIDS mice to listerial infection was mediated by CD4+ αβ T cells but neither by γδ T cells nor natural killer (NK) cells. Interferon-γ (IFN-γ) and interleukin-10 (IL-10) were produced by CD4+ T cells from Listeria-infected MAIDS mice in response to the in vitro stimulation with HKL, whereas IFN-γ but not IL-10 were produced by those from Listeria-infected control mice. These results suggest that T-helper 0 (Th0)-like immune responses of CD4+ T cells occur and participate in host defence mechanisms against listerial infection in MAIDS mice.

    Original languageEnglish
    Pages (from-to)532-538
    Number of pages7
    JournalImmunology
    Volume89
    Issue number4
    DOIs
    Publication statusPublished - Jan 1 1996

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    Murine Acquired Immunodeficiency Syndrome
    Listeria monocytogenes
    Retroviridae
    Coinfection
    T-Lymphocytes
    Listeria
    Infection
    Interleukin-10
    Interferons
    Hot Temperature
    Murine Leukemia Viruses
    Delayed Hypersensitivity
    Virus Diseases
    Cellular Immunity
    Natural Killer Cells

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes. / Hiromatsu, K.; Nishimura, H.; Kimura, K.; Aoki, Y.; Usami, J.; Kobayashi, N.; Makino, M.; Yoshikai, Y.

    In: Immunology, Vol. 89, No. 4, 01.01.1996, p. 532-538.

    Research output: Contribution to journalArticle

    Hiromatsu, K. ; Nishimura, H. ; Kimura, K. ; Aoki, Y. ; Usami, J. ; Kobayashi, N. ; Makino, M. ; Yoshikai, Y. / Th0-like CD4+ T cells protect mice with murine retrovirus-induced immunodeficiency syndrome (MAIDS) against co-infection with Listeria monocytogenes. In: Immunology. 1996 ; Vol. 89, No. 4. pp. 532-538.
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    abstract = "We examined the host defence mechanism against infection with Listeria monocytogenes, a facultative intracellular bacterium, in mice with murine acquired immunodeficiency syndrome (MAIDS) caused by LP-BM5 murine leukaemia virus (MuLv) infection. Although LP-BM5 MuLV infection in C57BL16 mice leads to a stage of immunodeficiency characterized by severe compromise of cell-mediated immunity, the mice with established MAIDS infected with LP-BM5 8 weeks previously, showed resistance to an intraperitoneal infection with Listeria monocytogenes. These MAIDS mice also showed resistance to a lethal dose of secondary listerial challenge, while the delayed-type hypersensitivity response to heat-killed Listeria (HKL) was severely impaired in MAIDS mice. The resistance of MAIDS mice to listerial infection was mediated by CD4+ αβ T cells but neither by γδ T cells nor natural killer (NK) cells. Interferon-γ (IFN-γ) and interleukin-10 (IL-10) were produced by CD4+ T cells from Listeria-infected MAIDS mice in response to the in vitro stimulation with HKL, whereas IFN-γ but not IL-10 were produced by those from Listeria-infected control mice. These results suggest that T-helper 0 (Th0)-like immune responses of CD4+ T cells occur and participate in host defence mechanisms against listerial infection in MAIDS mice.",
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