Th1/Th2 balance of SLE patients with lupus nephritis.

Hitoshi Nakashima, Mitsuteru Akahoshi, Kohsuke Masutani

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease that is characterized by the production of multiple autoantibodies and immune complex formation. Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of SLE. Although this pathogenetic mechanism in each histologically different type of nephritis remains unclear, recent findings in murine lupus elucidate an essential role for the Th1 cytokine in the development of diffuse lupus nephritis (DLN), and Th2 cytokine in that of membranous lupus nephritis (MLN). These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of lupus nephritis. Therefore the value of Th1/Th2 ratio of the peripheral CD4+ T cells in SLE patients could be a useful index to predict histopathology of lupus nephritis.

Original languageEnglish
Pages (from-to)706-713
Number of pages8
JournalRinsho byori. The Japanese journal of clinical pathology
Volume54
Issue number7
Publication statusPublished - Jul 2006

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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