The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation

V. Greger, J. H.M. Knoll, E. Woolf, K. Glatt, R. F. Tyndale, T. M. Delorey, R. W. Olsen, A. J. Tobin, J. M. Sikela, Y. Nakatsu, M. H. Brilliant, P. J. Whiting, M. Lalande

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Abstract

GABAA receptors are heterooligomeric ligand-gated ion channels that mediate the effect of the inhibitory neurotransmitter γ-aminobutyric acid. The GABAA receptors consist of at least 15 different receptor subunits that can be classified into 5 subfamilies (α, β, γ, δ, ρ{variant}) on the basis of sequence similarity. Chromosomal mapping studies have revealed that several of the GABAA receptor subunit genes appear to be organized as clusters. One such cluster, which consists of the GABAA receptor β3 (GABRB3) and α5 (GABRA5) subunit genes, is located in chromosome 15q11-q13. It is shown here that the GABAA receptor γ3 subunit gene (GABRG3) also maps to this region. Lambda and P1 phage clones surrounding both ends of GABRG3 were isolated; the clones derived from the 5′ end of GABRG3 were linked to an existing phage contig spanning the 3′ end of GABRA5. The two genes are located within 35 kb of each other and are transcribed in the same orientation.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalGenomics
Volume26
Issue number2
DOIs
Publication statusPublished - Mar 20 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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    Greger, V., Knoll, J. H. M., Woolf, E., Glatt, K., Tyndale, R. F., Delorey, T. M., Olsen, R. W., Tobin, A. J., Sikela, J. M., Nakatsu, Y., Brilliant, M. H., Whiting, P. J., & Lalande, M. (1995). The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Genomics, 26(2), 258-264. https://doi.org/10.1016/0888-7543(95)80209-5