The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation

V. Greger, J. H.M. Knoll, E. Woolf, K. Glatt, R. F. Tyndale, T. M. Delorey, R. W. Olsen, A. J. Tobin, J. M. Sikela, Yoshimichi Nakatsu, M. H. Brilliant, P. J. Whiting, M. Lalande

Research output: Contribution to journalArticle

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Abstract

GABAA receptors are heterooligomeric ligand-gated ion channels that mediate the effect of the inhibitory neurotransmitter γ-aminobutyric acid. The GABAA receptors consist of at least 15 different receptor subunits that can be classified into 5 subfamilies (α, β, γ, δ, ρ{variant}) on the basis of sequence similarity. Chromosomal mapping studies have revealed that several of the GABAA receptor subunit genes appear to be organized as clusters. One such cluster, which consists of the GABAA receptor β3 (GABRB3) and α5 (GABRA5) subunit genes, is located in chromosome 15q11-q13. It is shown here that the GABAA receptor γ3 subunit gene (GABRG3) also maps to this region. Lambda and P1 phage clones surrounding both ends of GABRG3 were isolated; the clones derived from the 5′ end of GABRG3 were linked to an existing phage contig spanning the 3′ end of GABRA5. The two genes are located within 35 kb of each other and are transcribed in the same orientation.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalGenomics
Volume26
Issue number2
DOIs
Publication statusPublished - Mar 20 1995
Externally publishedYes

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Human Chromosomes
GABA-A Receptors
Genes
Clone Cells
Bacteriophage P1
Ligand-Gated Ion Channels
Aminobutyrates
Bacteriophage lambda
Bacteriophages
Neurotransmitter Agents
Chromosomes
3-aminobutyric acid

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. / Greger, V.; Knoll, J. H.M.; Woolf, E.; Glatt, K.; Tyndale, R. F.; Delorey, T. M.; Olsen, R. W.; Tobin, A. J.; Sikela, J. M.; Nakatsu, Yoshimichi; Brilliant, M. H.; Whiting, P. J.; Lalande, M.

In: Genomics, Vol. 26, No. 2, 20.03.1995, p. 258-264.

Research output: Contribution to journalArticle

Greger, V, Knoll, JHM, Woolf, E, Glatt, K, Tyndale, RF, Delorey, TM, Olsen, RW, Tobin, AJ, Sikela, JM, Nakatsu, Y, Brilliant, MH, Whiting, PJ & Lalande, M 1995, 'The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation', Genomics, vol. 26, no. 2, pp. 258-264. https://doi.org/10.1016/0888-7543(95)80209-5
Greger, V. ; Knoll, J. H.M. ; Woolf, E. ; Glatt, K. ; Tyndale, R. F. ; Delorey, T. M. ; Olsen, R. W. ; Tobin, A. J. ; Sikela, J. M. ; Nakatsu, Yoshimichi ; Brilliant, M. H. ; Whiting, P. J. ; Lalande, M. / The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. In: Genomics. 1995 ; Vol. 26, No. 2. pp. 258-264.
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