The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

Werner E.G. Müller, Francisco J. Romero, Gabriela Pergande, Sanja Perovic, Manuel B. Graeber, Siegfried Kösel, Rupert Egensperger, Nina M. Schnopp, Parviz Mehraein, Masayuki Miura, Masato Okada, Alexander Von Holst, Frances B. Lefcort, Alfredo Rodriguez-Tébar, Jean Jacques Michaille, Danielle Dhouailly, Anders Bäckström, Ted Ebendal, Hermann Rohrer, M. SendtnerT. Michaelidis, C. Gravel, R. Götz, G. Ochs, K. V. Toyka, H. Thoenen, R. Egensperger, S. Kösel, P. Mehraein, M. B. Graeber, Shunsaku Homma, Ronald W. Oppenheim, Shin Kwak, Rolf Heumann, Frank Narz, Yildirim Algür, Daniela Bartsch, Martin Hüser, Franz Joseph Klinz, Erwin Wagner, Hartmut Berns, Kirstin Obst, Petra Wahle, H. Tanaka, M. Nakamura, M. Fukushima, K. Ohta, Leonard L. Jones, Richard B. Banati, Gennadij Raivich, Georg W. Kreutzberg, Christian Reiter, Zhiping Nie, Karl Friedrich Fischbach, Yutaka Eguchi, Shigeomi Shimizu, Yoshihide Tsujimoto, Alun M. Davies, Jimi Adu, Gayle Middleton, Yoshiyuki Kuchino, Chifumi Kitanaka, Akinori Sugiyama, Akio Asai, Ralf Gold, Hans Peter Hartung, Ichiro Matsuoka, Miwako Kobayashi, Miyuki Fujii, Kenzo Kurihara, Takashi Suda, Masato Tanaka, Masashi Adachi, Shigekazu Nagata, Seisuke Hattori, Michiyuki Matsuda, Shun Nakamura, Makoto Hamanoue, Mitsuru Machide, Kunio Matsumoto, Toshikazu Nakamura, Kazuyuki Nakajima, Shinichi Kohsaka, Akio Wanaka, Kazunori Imaizumi, Manabu Tsuda, Yuji Imai, Masaya Tohyama, Tsutomu Takagi, Y. A. Barde, Hans Georg Mannherz, Frank Rauch, Silvia Zanotti, Harald Stephan, Renate Paddenberg, Bernhard Polzar, Hartmut Engelmann, Sigrun Hess, Eva Gottfried

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Until now effective drugs for the treatment of Alzheimer's disease [AD] are not available. Here we show that flupirtine, a triaminopyridine derivative, which is successfully applied in clinics as a non-opiate analgesic drug protects rat cortical neurons against the ß-amyloid peptide [Aß]-induced cell death in vitro. The cells were treated for five days with 1 μM of the toxic fragment Aß25-35 in the presence or absence of flupirtine. 1 μM of Aß25-35 caused reduction of cell viability to 31.1 %. Preincubation of cells with 1 or 5 μg/ml of flupirtine resulted in a significant increase of the percentage of viable cells to 74.6 and 65.4 %, respectively. Due to the favourable pharmacokinetic profile and the potent neuroprotective effect, flupirtine is a promising drug for the treatment of neuronal loss in AD and probably other neurological diseases such as amyotrophic lateral sclerosis.

Original languageEnglish
Pages (from-to)575-600
Number of pages26
JournalJournal of Brain Research
Volume37
Issue number4
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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    Müller, W. E. G., Romero, F. J., Pergande, G., Perovic, S., Graeber, M. B., Kösel, S., Egensperger, R., Schnopp, N. M., Mehraein, P., Miura, M., Okada, M., Von Holst, A., Lefcort, F. B., Rodriguez-Tébar, A., Michaille, J. J., Dhouailly, D., Bäckström, A., Ebendal, T., Rohrer, H., ... Gottfried, E. (1996). The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs. Journal of Brain Research, 37(4), 575-600.