The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

Werner E.G. Müller; Francisco J. Romero; Gabriela Pergande; Sanja Perovic; Manuel B. Graeber; Siegfried Kösel; Rupert Egensperger; Nina M. Schnopp; Parviz Mehraein; Masayuki Miura; Masato Okada; Alexander Von Holst; Frances B. Lefcort; Alfredo Rodriguez-Tébar; Jean Jacques Michaille; Danielle Dhouailly; Anders Bäckström; Ted Ebendal; Hermann Rohrer; M. Sendtner; T. Michaelidis; C. Gravel; R. Götz; G. Ochs; K. V. Toyka; H. Thoenen; R. Egensperger; S. Kösel; P. Mehraein; M. B. Graeber; Shunsaku Homma; Ronald W. Oppenheim; Shin Kwak; Rolf Heumann; Frank Narz; Yildirim Algür; Daniela Bartsch; Martin Hüser; Franz Joseph Klinz; Erwin Wagner; Hartmut Berns; Kirstin Obst; Petra Wahle; H. Tanaka; M. Nakamura; M. Fukushima; K. Ohta; Leonard L. Jones; Richard B. Banati; Gennadij Raivich; Georg W. Kreutzberg; Christian Reiter; Zhiping Nie; Karl Friedrich Fischbach; Yutaka Eguchi; Shigeomi Shimizu; Yoshihide Tsujimoto; Alun M. Davies; Jimi Adu; Gayle Middleton; Yoshiyuki Kuchino; Chifumi Kitanaka; Akinori Sugiyama; Akio Asai; Ralf Gold; Hans Peter Hartung; Ichiro Matsuoka; Miwako Kobayashi; Miyuki Fujii; Kenzo Kurihara; Takashi Suda; Masato Tanaka; Masashi Adachi; Shigekazu Nagata; Seisuke Hattori; Michiyuki Matsuda; Shun Nakamura; Makoto Hamanoue; Mitsuru Machide; Kunio Matsumoto; Toshikazu Nakamura; Kazuyuki Nakajima; Shinichi Kohsaka; Akio Wanaka; Kazunori Imaizumi; Manabu Tsuda; Yuji Imai; Masaya Tohyama; Tsutomu Takagi; Y. A. Barde; Hans Georg Mannherz; Frank Rauch; Silvia Zanotti; Harald Stephan; Renate Paddenberg; Bernhard Polzar; Hartmut Engelmann; Sigrun Hess; Eva Gottfried

The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

Werner E.G. Müller, Francisco J. Romero, Gabriela Pergande, Sanja Perovic, Manuel B. Graeber, Siegfried Kösel, Rupert Egensperger, Nina M. Schnopp, Parviz Mehraein, Masayuki Miura, Masato Okada, Alexander Von Holst, Frances B. Lefcort, Alfredo Rodriguez-Tébar, Jean Jacques Michaille, Danielle Dhouailly, Anders Bäckström, Ted Ebendal, Hermann Rohrer, M. SendtnerT. Michaelidis, C. Gravel, R. Götz, G. Ochs, K. V. Toyka, H. Thoenen, R. Egensperger, S. Kösel, P. Mehraein, M. B. Graeber, Shunsaku Homma, Ronald W. Oppenheim, Shin Kwak, Rolf Heumann, Frank Narz, Yildirim Algür, Daniela Bartsch, Martin Hüser, Franz Joseph Klinz, Erwin Wagner, Hartmut Berns, Kirstin Obst, Petra Wahle, H. Tanaka, M. Nakamura, M. Fukushima, K. Ohta, Leonard L. Jones, Richard B. Banati, Gennadij Raivich, Georg W. Kreutzberg, Christian Reiter, Zhiping Nie, Karl Friedrich Fischbach, Yutaka Eguchi, Shigeomi Shimizu, Yoshihide Tsujimoto, Alun M. Davies, Jimi Adu, Gayle Middleton, Yoshiyuki Kuchino, Chifumi Kitanaka, Akinori Sugiyama, Akio Asai, Ralf Gold, Hans Peter Hartung, Ichiro Matsuoka, Miwako Kobayashi, Miyuki Fujii, Kenzo Kurihara, Takashi Suda, Masato Tanaka, Masashi Adachi, Shigekazu Nagata, Seisuke Hattori, Michiyuki Matsuda, Shun Nakamura, Makoto Hamanoue, Mitsuru Machide, Kunio Matsumoto, Toshikazu Nakamura, Kazuyuki Nakajima, Shinichi Kohsaka, Akio Wanaka, Kazunori Imaizumi, Manabu Tsuda, Yuji Imai, Masaya Tohyama, Tsutomu Takagi, Y. A. Barde, Hans Georg Mannherz, Frank Rauch, Silvia Zanotti, Harald Stephan, Renate Paddenberg, Bernhard Polzar, Hartmut Engelmann, Sigrun Hess, Eva Gottfried

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Until now effective drugs for the treatment of Alzheimer's disease [AD] are not available. Here we show that flupirtine, a triaminopyridine derivative, which is successfully applied in clinics as a non-opiate analgesic drug protects rat cortical neurons against the ß-amyloid peptide [Aß]-induced cell death in vitro. The cells were treated for five days with 1 μM of the toxic fragment Aß25-35 in the presence or absence of flupirtine. 1 μM of Aß25-35 caused reduction of cell viability to 31.1 %. Preincubation of cells with 1 or 5 μg/ml of flupirtine resulted in a significant increase of the percentage of viable cells to 74.6 and 65.4 %, respectively. Due to the favourable pharmacokinetic profile and the potent neuroprotective effect, flupirtine is a promising drug for the treatment of neuronal loss in AD and probably other neurological diseases such as amyotrophic lateral sclerosis.

Original language	English
Pages (from-to)	575-600
Number of pages	26
Journal	Journal of Brain Research
Volume	37
Issue number	4
Publication status	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Neuropsychology and Physiological Psychology

Cite this

Müller, W. E. G., Romero, F. J., Pergande, G., Perovic, S., Graeber, M. B., Kösel, S., Egensperger, R., Schnopp, N. M., Mehraein, P., Miura, M., Okada, M., Von Holst, A., Lefcort, F. B., Rodriguez-Tébar, A., Michaille, J. J., Dhouailly, D., Bäckström, A., Ebendal, T., Rohrer, H., ... Gottfried, E. (1996). The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs. Journal of Brain Research, 37(4), 575-600.

Müller, WEG, Romero, FJ, Pergande, G, Perovic, S, Graeber, MB, Kösel, S, Egensperger, R, Schnopp, NM, Mehraein, P, Miura, M, Okada, M, Von Holst, A, Lefcort, FB, Rodriguez-Tébar, A, Michaille, JJ, Dhouailly, D, Bäckström, A, Ebendal, T, Rohrer, H, Sendtner, M, Michaelidis, T, Gravel, C, Götz, R, Ochs, G, Toyka, KV, Thoenen, H, Egensperger, R, Kösel, S, Mehraein, P, Graeber, MB, Homma, S, Oppenheim, RW, Kwak, S, Heumann, R, Narz, F, Algür, Y, Bartsch, D, Hüser, M, Klinz, FJ, Wagner, E, Berns, H, Obst, K, Wahle, P, Tanaka, H, Nakamura, M, Fukushima, M, Ohta, K, Jones, LL, Banati, RB, Raivich, G, Kreutzberg, GW, Reiter, C, Nie, Z, Fischbach, KF, Eguchi, Y, Shimizu, S, Tsujimoto, Y, Davies, AM, Adu, J, Middleton, G, Kuchino, Y, Kitanaka, C, Sugiyama, A, Asai, A, Gold, R, Hartung, HP, Matsuoka, I, Kobayashi, M, Fujii, M, Kurihara, K, Suda, T, Tanaka, M, Adachi, M, Nagata, S, Hattori, S, Matsuda, M, Nakamura, S, Hamanoue, M, Machide, M, Matsumoto, K, Nakamura, T, Nakajima, K, Kohsaka, S, Wanaka, A, Imaizumi, K, Tsuda, M, Imai, Y, Tohyama, M, Takagi, T, Barde, YA, Mannherz, HG, Rauch, F, Zanotti, S, Stephan, H, Paddenberg, R, Polzar, B, Engelmann, H, Hess, S & Gottfried, E 1996, 'The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs', Journal of Brain Research, vol. 37, no. 4, pp. 575-600.

@article{b356d642d48f40b488af039e3e703938,

title = "The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs",

abstract = "Until now effective drugs for the treatment of Alzheimer's disease [AD] are not available. Here we show that flupirtine, a triaminopyridine derivative, which is successfully applied in clinics as a non-opiate analgesic drug protects rat cortical neurons against the {\ss}-amyloid peptide [A{\ss}]-induced cell death in vitro. The cells were treated for five days with 1 μM of the toxic fragment A{\ss}25-35 in the presence or absence of flupirtine. 1 μM of A{\ss}25-35 caused reduction of cell viability to 31.1 %. Preincubation of cells with 1 or 5 μg/ml of flupirtine resulted in a significant increase of the percentage of viable cells to 74.6 and 65.4 %, respectively. Due to the favourable pharmacokinetic profile and the potent neuroprotective effect, flupirtine is a promising drug for the treatment of neuronal loss in AD and probably other neurological diseases such as amyotrophic lateral sclerosis.",

author = "M{\"u}ller, {Werner E.G.} and Romero, {Francisco J.} and Gabriela Pergande and Sanja Perovic and Graeber, {Manuel B.} and Siegfried K{\"o}sel and Rupert Egensperger and Schnopp, {Nina M.} and Parviz Mehraein and Masayuki Miura and Masato Okada and {Von Holst}, Alexander and Lefcort, {Frances B.} and Alfredo Rodriguez-T{\'e}bar and Michaille, {Jean Jacques} and Danielle Dhouailly and Anders B{\"a}ckstr{\"o}m and Ted Ebendal and Hermann Rohrer and M. Sendtner and T. Michaelidis and C. Gravel and R. G{\"o}tz and G. Ochs and Toyka, {K. V.} and H. Thoenen and R. Egensperger and S. K{\"o}sel and P. Mehraein and Graeber, {M. B.} and Shunsaku Homma and Oppenheim, {Ronald W.} and Shin Kwak and Rolf Heumann and Frank Narz and Yildirim Alg{\"u}r and Daniela Bartsch and Martin H{\"u}ser and Klinz, {Franz Joseph} and Erwin Wagner and Hartmut Berns and Kirstin Obst and Petra Wahle and H. Tanaka and M. Nakamura and M. Fukushima and K. Ohta and Jones, {Leonard L.} and Banati, {Richard B.} and Gennadij Raivich and Kreutzberg, {Georg W.} and Christian Reiter and Zhiping Nie and Fischbach, {Karl Friedrich} and Yutaka Eguchi and Shigeomi Shimizu and Yoshihide Tsujimoto and Davies, {Alun M.} and Jimi Adu and Gayle Middleton and Yoshiyuki Kuchino and Chifumi Kitanaka and Akinori Sugiyama and Akio Asai and Ralf Gold and Hartung, {Hans Peter} and Ichiro Matsuoka and Miwako Kobayashi and Miyuki Fujii and Kenzo Kurihara and Takashi Suda and Masato Tanaka and Masashi Adachi and Shigekazu Nagata and Seisuke Hattori and Michiyuki Matsuda and Shun Nakamura and Makoto Hamanoue and Mitsuru Machide and Kunio Matsumoto and Toshikazu Nakamura and Kazuyuki Nakajima and Shinichi Kohsaka and Akio Wanaka and Kazunori Imaizumi and Manabu Tsuda and Yuji Imai and Masaya Tohyama and Tsutomu Takagi and Barde, {Y. A.} and Mannherz, {Hans Georg} and Frank Rauch and Silvia Zanotti and Harald Stephan and Renate Paddenberg and Bernhard Polzar and Hartmut Engelmann and Sigrun Hess and Eva Gottfried",

year = "1996",

language = "English",

volume = "37",

pages = "575--600",

journal = "Journal of Brain Research",

issn = "0944-8160",

publisher = "Akademie Verlag GMBH",

number = "4",

}

TY - JOUR

T1 - The 3rd German-Japanese Joint Workshop. Cell Death in the CNS

T2 - Molecules and Programs

AU - Müller, Werner E.G.

AU - Romero, Francisco J.

AU - Pergande, Gabriela

AU - Perovic, Sanja

AU - Graeber, Manuel B.

AU - Kösel, Siegfried

AU - Egensperger, Rupert

AU - Schnopp, Nina M.

AU - Mehraein, Parviz

AU - Miura, Masayuki

AU - Okada, Masato

AU - Von Holst, Alexander

AU - Lefcort, Frances B.

AU - Rodriguez-Tébar, Alfredo

AU - Michaille, Jean Jacques

AU - Dhouailly, Danielle

AU - Bäckström, Anders

AU - Ebendal, Ted

AU - Rohrer, Hermann

AU - Sendtner, M.

AU - Michaelidis, T.

AU - Gravel, C.

AU - Götz, R.

AU - Ochs, G.

AU - Toyka, K. V.

AU - Thoenen, H.

AU - Egensperger, R.

AU - Kösel, S.

AU - Mehraein, P.

AU - Graeber, M. B.

AU - Homma, Shunsaku

AU - Oppenheim, Ronald W.

AU - Kwak, Shin

AU - Heumann, Rolf

AU - Narz, Frank

AU - Algür, Yildirim

AU - Bartsch, Daniela

AU - Hüser, Martin

AU - Klinz, Franz Joseph

AU - Wagner, Erwin

AU - Berns, Hartmut

AU - Obst, Kirstin

AU - Wahle, Petra

AU - Tanaka, H.

AU - Nakamura, M.

AU - Fukushima, M.

AU - Ohta, K.

AU - Jones, Leonard L.

AU - Banati, Richard B.

AU - Raivich, Gennadij

AU - Kreutzberg, Georg W.

AU - Reiter, Christian

AU - Nie, Zhiping

AU - Fischbach, Karl Friedrich

AU - Eguchi, Yutaka

AU - Shimizu, Shigeomi

AU - Tsujimoto, Yoshihide

AU - Davies, Alun M.

AU - Adu, Jimi

AU - Middleton, Gayle

AU - Kuchino, Yoshiyuki

AU - Kitanaka, Chifumi

AU - Sugiyama, Akinori

AU - Asai, Akio

AU - Gold, Ralf

AU - Hartung, Hans Peter

AU - Matsuoka, Ichiro

AU - Kobayashi, Miwako

AU - Fujii, Miyuki

AU - Kurihara, Kenzo

AU - Suda, Takashi

AU - Tanaka, Masato

AU - Adachi, Masashi

AU - Nagata, Shigekazu

AU - Hattori, Seisuke

AU - Matsuda, Michiyuki

AU - Nakamura, Shun

AU - Hamanoue, Makoto

AU - Machide, Mitsuru

AU - Matsumoto, Kunio

AU - Nakamura, Toshikazu

AU - Nakajima, Kazuyuki

AU - Kohsaka, Shinichi

AU - Wanaka, Akio

AU - Imaizumi, Kazunori

AU - Tsuda, Manabu

AU - Imai, Yuji

AU - Tohyama, Masaya

AU - Takagi, Tsutomu

AU - Barde, Y. A.

AU - Mannherz, Hans Georg

AU - Rauch, Frank

AU - Zanotti, Silvia

AU - Stephan, Harald

AU - Paddenberg, Renate

AU - Polzar, Bernhard

AU - Engelmann, Hartmut

AU - Hess, Sigrun

AU - Gottfried, Eva

PY - 1996

Y1 - 1996

N2 - Until now effective drugs for the treatment of Alzheimer's disease [AD] are not available. Here we show that flupirtine, a triaminopyridine derivative, which is successfully applied in clinics as a non-opiate analgesic drug protects rat cortical neurons against the ß-amyloid peptide [Aß]-induced cell death in vitro. The cells were treated for five days with 1 μM of the toxic fragment Aß25-35 in the presence or absence of flupirtine. 1 μM of Aß25-35 caused reduction of cell viability to 31.1 %. Preincubation of cells with 1 or 5 μg/ml of flupirtine resulted in a significant increase of the percentage of viable cells to 74.6 and 65.4 %, respectively. Due to the favourable pharmacokinetic profile and the potent neuroprotective effect, flupirtine is a promising drug for the treatment of neuronal loss in AD and probably other neurological diseases such as amyotrophic lateral sclerosis.

AB - Until now effective drugs for the treatment of Alzheimer's disease [AD] are not available. Here we show that flupirtine, a triaminopyridine derivative, which is successfully applied in clinics as a non-opiate analgesic drug protects rat cortical neurons against the ß-amyloid peptide [Aß]-induced cell death in vitro. The cells were treated for five days with 1 μM of the toxic fragment Aß25-35 in the presence or absence of flupirtine. 1 μM of Aß25-35 caused reduction of cell viability to 31.1 %. Preincubation of cells with 1 or 5 μg/ml of flupirtine resulted in a significant increase of the percentage of viable cells to 74.6 and 65.4 %, respectively. Due to the favourable pharmacokinetic profile and the potent neuroprotective effect, flupirtine is a promising drug for the treatment of neuronal loss in AD and probably other neurological diseases such as amyotrophic lateral sclerosis.

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UR - http://www.scopus.com/inward/citedby.url?scp=1842418810&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:1842418810

SN - 0944-8160

VL - 37

SP - 575

EP - 600

JO - Journal of Brain Research

JF - Journal of Brain Research

IS - 4

ER -

The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

Abstract

All Science Journal Classification (ASJC) codes

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