The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations

Kuniyoshi Shimizu, Masayuki Fukuda, Ryuichiro Kondo, Kokki Sakai

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalPlanta Medica
Volume66
Issue number1
DOIs
Publication statusPublished - 2000

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Artocarpus
Artocarpus altilis
heartwood
inhibitory concentration 50
Oxidoreductases
Inhibitory Concentration 50
linolenic acid
methanol
alpha-Linolenic Acid
Methanol
extracts

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

The 5α-reductase inhibitory components from heartwood of Artocarpus incisus : Structure-activity investigations. / Shimizu, Kuniyoshi; Fukuda, Masayuki; Kondo, Ryuichiro; Sakai, Kokki.

In: Planta Medica, Vol. 66, No. 1, 2000, p. 16-19.

Research output: Contribution to journalArticle

Shimizu, Kuniyoshi ; Fukuda, Masayuki ; Kondo, Ryuichiro ; Sakai, Kokki. / The 5α-reductase inhibitory components from heartwood of Artocarpus incisus : Structure-activity investigations. In: Planta Medica. 2000 ; Vol. 66, No. 1. pp. 16-19.
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