The absolute configuration and total synthesis of korormicin

Hisatoshi Uehara, Tohru Oishi, Kazuhiro Yoshikawa, Kenichi Mochida, Masahiro Hirama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The marine antibiotic korormicin, isolated from the culture filtrate of marine bacterial strain Pseudoalteromonas sp. F-420, specifically inhibits the growth of marine Gram-negative bacteria without affecting terrestrial species. The absolute configuration of korormicin was determined by the combination of a CD exciton chirality method and chemical degradation. Convergent total synthesis of korormicin has been also achieved.

Original languageEnglish
Pages (from-to)8641-8645
Number of pages5
JournalTetrahedron Letters
Volume40
Issue number49
DOIs
Publication statusPublished - Dec 3 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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