The action of the cholecystokinin-A receptor antagonist, devazepide, on the digestive system of the chicken

M. Furuse, Y. H. Choi, S. Satoh, J. Okumura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The influence of the cholecystokinin (CCK)-A receptor antagonist, devazepide (DVZ), on the chicken digestive tract was investigated. The passage of food from the crops of birds treated with DVZ was not significantly different from that of the control. DVZ treatment did not inhibit the biliary flow stimulated by the CCK analogue, caerulein. Dispersed chicken pancreatic acini stimulated with CCK were treated with various concentrations of DVZ. At 10-5 M, DVZ completely inhibited amylase release; this concentration was much higher than those reported to have similar effects in mammals. The results suggest that the action DVZ as a CCK antagonist in the chicken is very weak.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalExperientia
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 1 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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