The Ada protein is a class I transcription factor of Escherichia coli

K. Sakumi, K. Igarashi, M. Sekiguchi, A. Ishihama

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The methylated Ada protein of Escherichia coli, a regulatory protein for the adaptive response, binds to a target DNA from positions -62 to -31 upstream of the ada gene and facilitates the binding of RNA polymerase to the promoter. Mutant RNA polymerases consisting of C-terminal-deleted α subunits are virtually inactive in response to activation by the Ada protein. Thus, we conclude that the Ada protein is a class I transcription factor which requires the C-terminal region of the RNA polymerase α subunit for transcription activation.

Original languageEnglish
Pages (from-to)2455-2457
Number of pages3
JournalJournal of bacteriology
Issue number8
Publication statusPublished - Jan 1 1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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